泼尼松对原发性肾病综合征患儿血清胰岛素样生长因子1、骨钙素及骨密度的影响  

Effects of Prednisone on Serum Insulin-Like Growth Factor 1, Osteocalcin and Bone Mineral Density in Children with Primary Nephrotic Syndrome

作　　者：曾海江[1] 易玲[1] 钟涛[1] 黄郁波[1] ZENG Haijiang;YI Ling;ZHONG Tao;HUANG Yubo(Dept.of Pediatrics, Ganzhou People's Hospital, Jiangxi Ganzhou 341000, China)

机构地区：[1]赣州市人民医院儿科,江西赣州341000

出　　处：《中国医院用药评价与分析》2018年第12期1618-1619,1621,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：赣州市科学技术局项目(No.GZ2016ZSF083)

摘　　要：目的:探讨泼尼松对原发性肾病综合征患儿血清胰岛素样生长因子1(IGF-1)、骨钙素及骨密度的影响。方法:选取2016年3月至2017年6月间赣州市人民医院收治的初诊原发性肾病综合征患儿24例作为观察组(采用口服泼尼松治疗),筛选同期儿保门诊健康儿童24例作为对照组。测定并记录观察组患儿治疗前、治疗第4周、第8周及第12周的骨密度、血清IGF-1和骨钙素水平,并与对照组儿童对比。结果:治疗前,观察组患儿血清IGF-1和骨钙素水平明显低于对照组,差异均有统计学意义(P<0.05),而骨密度水平的差异无统计学意义(P>0.05);治疗第4—12周,观察组患儿的血清IGF-1和骨钙素水平呈明显升高趋势,而骨密度呈明显降低趋势,差异均有统计学意义(P<0.05);治疗第4、8及12周,观察组患儿血清IGF-1和骨钙素水平明显高于治疗前,但骨密度水平明显低于治疗前,差异均有统计学意义(P<0.05)。结论:泼尼松能改善原发性肾病综合征患儿血清IGF-1和骨钙素水平,但是长期应用可致骨密度减少,造成骨量丢失。OBJECTIVE: To investigate the effects of prednisone on serum insulin-like growth factor 1(IGF-1), osteocalcin and bone mineral density in children with primary nephrotic syndrome. METHODS: Twenty-four children with newly diagnosed primary nephrotic syndrome admitted to Cangzhou People’s Hospital from Mar. 2016 to Jun. 2017 were selected as the observation group(oral prednisone treatment), and twenty-four healthy children in the outpatient child care department in the same period were selected as the control group. Bone mineral density, levels of serum IGF-1 and osteocalcin were measured and recorded in the observation group before treatment, at 4 th week, 8 th week and 12 th week, and compared with those in the control group. RESULTS: Before treatment, the levels of serum IGF-1 and osteocalcin in observation group were significantly lower than those in control group(P<0.05), but the difference in bone mineral density was not statistically significant(P>0.05). At the 4 th to 12 th week of treatment, the levels of serum IGF-1 and osteocalcin in the observation group showed a significant increase, while the bone mineral density decreased significantly, the difference was statistically significant(P<0.05). At the 4 th, 8 th and 12 th week of treatment, the levels of serum IGF-1 and osteocalcin in observation group were significantly higher than those before treatment, but the bone mineral density was significantly lower than before treatment, the differences were statistically significant(P<0.05). CONCLUSIONS: Prednisone can improve the levels of serum IGF-1 and osteocalcin in children with primary nephrotic syndrome, but long-term application can reduce the bone mineral density and cause the bone loss.

关 键 词：儿童原发性肾病综合征 骨钙素 骨密度 胰岛素样生长因子 

分 类 号：R977.11[医药卫生—药品]