含哒嗪酮结构的L-缬氨酸取代去甲斑蝥素衍生物的制备与应用  

Preparation and Application of L-valine Substituted Norcantharidin Derivatives Containing Pyridazine Ketone

作　　者：李倩 王玮 LI Qian;WANG Wei(School of Chemistry and Chemical Engineering,Shaoxing University,Shaoxing,Zhejiang 312000;Yuanpei College,Shaoxing University,Shaoxing,Zhejiang 312000)

机构地区：[1]绍兴文理学院化学化工学院,浙江绍兴312000 [2]绍兴文理学院元培学院,浙江绍兴312000

出　　处：《绍兴文理学院学报》2018年第9期57-60,共4页Journal of Shaoxing University

基　　金：国家自然科学基金资助项目(81202411)

摘　　要：采用1,3-偶极环加成方法,在L-缬氨酸取代去甲斑蝥素结构中的C5和C6位引入吡唑环,进而与含哒嗪酮结构的色酮醛腙反应导入哒嗪酮结构,生成含哒嗪酮结构的L-缬氨酸取代去甲斑蝥素衍生物.该衍生物具有多种生物活性,可用于潜在药物的开发研究.In this paper,the pyrazole ring was introduced into the structure of L-valine replaced norcantharidin in C5 and C6positions by 1,3-dipolar ring addition method;,the structure of pyridazine was then introduced into the structure of pyridazine through reaction with tryptoprozone containing azone structure; the Lvalrine containing pyridazine ketone was generated to replace the derivatives of norcantharidin. This derivative has a variety of biological activities,thus used in the development and research of potential drugs.

关 键 词：L-缬氨酸取代去甲斑蝥素衍生物 哒嗪酮结构 生物活性 

分 类 号：O641[理学—物理化学]