受体活性修饰蛋白1促进成骨作用的研究进展  

Advancements in receptor activity-modifying protein-1 for osteogenesis

作　　者：张勤 宫苹[1] Zhang Qin;Gong Ping(State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Implantation,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院种植科,成都610041

出　　处：《国际口腔医学杂志》2019年第1期30-36,共7页International Journal of Stomatology

基　　金：国家自然科学基金(81571008;81701007);四川省科技计划(2018RZ0087);中央高校基本科研业务费专项资金(2017SCU-12056;2018SCUH0006);中国博士后科学基金资助项目(2018M-631091);四川大学华西口腔医院青年科学研究基金项目(2016-11)~~

摘　　要：生理状态下,骨吸收与骨形成过程的动态平衡对维持骨组织功能至关重要。而在骨损伤状态下,如何通过促进骨形成,抑制骨吸收从而促进骨愈合过程一直是该领域研究的热点。近年来,受体活性修饰蛋白-1(RAMP1)在骨代谢过程中的调节作用已受到越来越多的关注。RAMP1广泛存在于骨组织中,它可以与不同的G蛋白偶联受体(GPCR)结合,修饰受体行为,调节相应的配体作用。此外,它还能进一步参与到受体介导的信号转导中,影响成骨相关细胞内蛋白的相互作用,从而影响成骨相关细胞增殖、迁移、分化等生物学特性。本文就近年来RAMP1促进成骨作用的研究作一综述。Under physiological conditions,the dynamic balance between bone resorption and bone formation is necessary to maintain bone tissue function.However,whether we can further accelerate or improve osteogenesis process during bone wound healing has been widely explored.Receptor activity-modifying protein-1(RAMP1)has been extensively investigated because of its extensive biological activities,especially its effects on bone fracture repair.RAMP1 is commonly found in bone tissues and can interact with G-protein coupled receptors to modify their activities.RAMP1 also has a broader role in regulating receptor trafficking and signaling,affecting the biological characteristics of osteoblasts,such as proliferation,migration,and differentiation.Thus,this review summarizes recent studies about the effects of RAMP1 on osteogenesis.

关 键 词：受体活性修饰蛋白1 降钙素基因相关肽 成骨作用 G蛋白偶联受体 降钙素受体样受体 

分 类 号：Q51[生物学—生物化学]