恶性肿瘤患者免疫功能与抗核抗体的关系研究  

Relationship between immune function and antinuclear antibody in malignancy

作　　者：李亚波[1] 林云[1] 邹映东[1] 刘骥[2] LI Yabo;LIN Yun;ZOU Yingdong;LIU Ji(Department of Clinical Laboratory,Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming,Yunnan 650021,China;Department of Otolaryngological,the First People′sHospital of Kunming,Kunming,Yunnan 650011,China)

机构地区：[1]云南省中医医院检验科,昆明650021 [2]云南省昆明市第一人民医院耳鼻喉科,650011

出　　处：《检验医学与临床》2019年第1期48-50,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨恶性肿瘤患者免疫功能与抗核抗体的关系。方法采集2010―2016年云南省中医医院190例恶性肿瘤患者作为恶性肿瘤组,选择同期40例体检健康者作为对照组。收集2组研究对象的血清抗核抗体(ANA)水平;检测恶性肿瘤组患者外周血淋巴细胞亚群水平,并按ANA水平分为ANA阳性组和阴性组,比较2组患者淋巴细胞亚群水平。结果 ANA滴度≥1∶100作为阳性判断标准时,190例恶性肿瘤组患者ANA阳性率为34.2%,ANA滴度>1∶320时,阳性率为24.2%。对照组ANA阳性率为5.0%。2种情况下,2组研究对象的ANA阳性率比较,差异均有统计学意义(P<0.05)。恶性肿瘤组患者ANA阴性组CD4^+/CD8^+为1.79(1.16,2.11),阳性组CD4^+/CD8^+为1.25(1.02,1.56),差异有统计学意义(P<0.05)。结论恶性肿瘤患者体内存在以ANA升高为表现的自身免疫现象,ANA阳性患者免疫功能处于抑制状态,自身免疫反应导致阳性组和阴性组细胞免疫功能的差异。Objective To explore the correlationship between immune function and antinuclear antibody in malignancy.Methods The data of serum autoantibodies in 190 malignancy patients and 40 health people(control group)during 2010―2016 were collected.The differences of antibodies level between 2 groups were analyzed.The data of peripheral blood lymphocyte subsets in 190 malignancy patients were collected and divided into 2 groups according to the ANA levels:ANA positive group and ANA negative group.The differences of peripheral blood lymphocyte subsets level between 2 groups were analyzed.Results When the ANA≥1∶100 as a positive criterion,the positive rate of ANA in 190 patients with malignant tumors was 34.2%.The ANA titer increased to 1∶320,the positive rate was 24.2%.The positive rate of ANA in healthy control group was 5.0%.The positive rate of ANA in the above two criteria were significantly higher than that in healthy control group(P<0.05).CD4^+/CD8^+of ANA negative malignancy group was 1.79(1.16,2.11),CD4^+/CD8^+of ANA positive malignancy group was 1.25(1.02,1.56),the level of CD4^+/CD8^+had statistical difference between 2 groups(P<0.05).Conclusion Autoimmune phenomena exist in malignancy patients in the form of antinuclear antibody.The immune function of ANA-positive group is inhibited compared with ANA-negative group.The autoimmune reaction is the cause of the difference Possible Causes.

关 键 词：恶性肿瘤 自身免疫性疾病 抗核抗体 淋巴细胞亚群 

分 类 号：R446.63[医药卫生—诊断学]