莫西沙星对慢性支气管炎急性发作期血气指标、内皮素-1等炎性因子水平的影响  

Effects of moxifloxacin on blood gas,ET-1 and other related factors in acute exacerbation of chronic bronchitis

作　　者：武金银[1] WU Jinyin(Department of Pharmacy,Puyang Oilfield General Hospital,Puyang,Henan457001,China)

机构地区：[1]濮阳市油田总医院药剂科,河南濮阳457001

出　　处：《安徽医药》2019年第1期176-179,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨慢性支气管炎急性发作期病人使用莫西沙星治疗对血气指标、内皮素-1(ET-1)等炎性因子水平的影响。方法选取2015年1月至2016年1月在濮阳市油田总医院治疗的100例慢性支气管炎急性发作期病人,采用随机数字表法分为莫西沙星组、左氧氟沙星组各50例,两组均采用祛痰、止咳吸氧、解痉等基础治疗,对比两组治疗前后的血气指标、血清炎性因子及ET-1。结果治疗后,莫西沙星组病人的C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、ET-1、动脉血二氧化碳分压(Pa CO2)均低于左氧氟沙星组(t值分别为3. 679、4. 912、3. 831、6. 357、6. 775、1. 079,P <0. 05),莫西沙星组病人的动脉血氧分压(Pa O2)、血氧饱和度(Sa O2)均高于左氧氟沙星组(t值分别为:2. 184、4. 074,P <0. 05);莫西沙星组病人的咳嗽咳痰、发热、呼吸困难、肺部啰音消失时间低于左氧氟沙星组(t值分别为:4. 275、3. 679、3. 909、3. 923,P <0. 05)。莫西沙星组病人的显效率80%、有效率16%,左氧氟沙星组显效率60%、有效率30%,两组疗效比较差异有统计学意义(Z=-2. 004,P <0. 05)。结论慢性支气管炎急性发作期病人使用莫西沙星治疗能更加显著的改善病人的血气指标水平及降低CRP、TNF-α、IL-6、IL-8、ET-1水平,提高治疗效果。Objective To investigate the effects of moxifloxacin on blood gas,ET-1 and other related factors in patients with acute exacerbation of chronic bronchitis.Methods 100 cases of patients with acute exacerbation of chronic bronchitis from January 2015 to January 2016 in our hospital were selected and randomly divided into moxifloxacin group and levofloxacin group with 50 cases in each group by random number table method.The two groups were treated with oxygen,cough expectorant and antispasmodic therapy.The levels of blood gas,serum inflammatory factors and endothelin-1(ET-1)in two groups were compared before and after treatment.Results After treatment,the levels of CRP,TNF-,IL-6,IL-8,ET-1 and PaCO 2 in the moxifloxacin group were lower than those in the levofloxacin group,and the difference was statistically significant(The t values are 3.679、4.912、3.831、6.357、6.775、1.079,P<0.05),The PaO 2 and SaO 2 in the moxifloxacin group were higher than those in the levofloxacin group,and the difference was statistically significant(The t values are:2.184,4.074,P<0.05);The time of cough,expectoration,fever,dyspnea and pulmonary rales in moxifloxacin group was lower than that in levofloxacin group,and the difference was statistically significant(The t values are:4.275,3.679,3.909,3.923,P<0.05).The effective rate of moxifloxacin group was 80%,effective rate was 16%,the effective rate of levofloxacin group was 60%,and the effective rate was 30%,the difference in efficacy between the two groups was statistically significant(Z=-2.004,P<0.05).Conclusion For patients with acute exacerbation of chronic bronchitis,moxifloxacin treatment can significantly improve the blood gas levels and CRP,TNF-α,IL-6,IL-8,ET-1 levels,improve the therapeutic effect.

关 键 词：支气管炎 慢性 莫西沙星 受体 内皮素A 肿瘤坏死因子α 白细胞介素类 血气分析 C反应蛋白质 

分 类 号：R562.21[医药卫生—呼吸系统]