氧化应激对动物有腔卵泡闭锁的影响及机制  

Effect of oxidative stress on antral follicular atresia in animals and its mechanism

作　　者：刘红林[1] 孟繁星[1] LIU Honglin;MENG Fanxing(College of Animal Science and Technology,Nanjing Agricultural University,Nanjing 210095,China)

机构地区：[1]南京农业大学动物科技学院,江苏南京210095

出　　处：《南京农业大学学报》2019年第1期6-13,共8页Journal of Nanjing Agricultural University

基　　金：国家自然科学基金重点项目(31630072)

摘　　要：氧化应激被认为是影响动物繁殖性能和造成人类不孕不育的重要因素,氧化应激诱导卵泡颗粒细胞凋亡,进而诱发卵泡闭锁是其影响动物繁殖性能的重要途径。近年来,针对氧化应激对有腔卵泡闭锁的影响研究取得了系列进展,主要包括:氧化应激对卵泡闭锁具有重要调控作用;叉头盒转录因子O1(FoxO1)是氧化应激诱发卵泡闭锁的关键性调控因子;卵泡液因子能够调控卵泡颗粒细胞氧化损伤的发生与程度。Oxidative stress is considered to be an important factor affecting animal reproductive performance and causing infertility in humans. Oxidative stress induces apoptosis of follicular granulosa cells,which in turn induces follicular atresia as an important way to influence animal reproductive performance. In recent years,a series of research progress has been made on the effects of oxidative stress on antral follicular atresia,including:oxidative stress plays an important role in regulating follicular atresia;transcription factor forkhead box O1(FoxO1)is a key regulator of oxidative stress-induced follicular atresia;follicular fluid factors can regulate the occurrence and degree of oxidative damage of follicular granule cells.

关 键 词：氧化应激 卵泡闭锁 动物繁殖 FOXO1 

分 类 号：S814.1[农业科学—畜牧学]