温阳活血法联合常规治疗对阳虚血瘀型3～4期慢性肾脏病患者的临床疗效  

Clinical effects of Warming Yang and Promoting Blood Circulation Method combined with conventional treatment on patients with stage 3-4 chronic kidney disease due to Yang Deficiency and Blood Stasis

作　　者：赵爱萍[1] 吴洋洋[2] 吴竞[1] 丘余良[1] 何姜兰 ZHAO Ai-ping;WU Yang-yang;WU Jing;QIU Yu-liang;HE Jiang-lan(Fujian Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Nephropathy; Department of Nephrology, People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350004, China;Department of Nephrology, The Second People’s Hospital Affili. ated to Fujian University of Traditional Chinese Medicine, Fuzhou 350003, China)

机构地区：[1]福建中医药大学附属人民医院肾内科福建省中西医结合肾病重点实验室,福建福州350004 [2]福建中医药大学附属第二人民医院肾内科,福建福州350003

出　　处：《中成药》2019年第1期70-74,共5页Chinese Traditional Patent Medicine

基　　金：福建省卫生厅中医药科研课题(wzsb201303)

摘　　要：目的探讨温阳活血法联合常规治疗对阳虚血瘀型3～4期慢性肾脏病患者的临床疗效。方法 80例患者随机分为治疗组和对照组,每组40例,对照组给予常规治疗,治疗组在对照组基础上加用温阳活血法(真武汤联合桃核承气汤),3个月为1个疗程。然后,Pearson分析考察不对称二甲基精氨酸(ADMA)与肾功能指标的相关性,观察2组临床疗效、肾功能指标、不良反应。结果治疗组总有效率显著高于对照组(P<0. 05)。治疗后,2组血肌酐(Scr)、尿素氮(BUN)、ADMA显著降低(P<0. 05),估算肾小球滤过率(e GFR)显著升高(P<0. 05),以治疗组更显著(P<0. 05)。Scr、BUN与ADMA呈正相关性(P<0. 05),而e GFR与后者呈负相关性(P<0. 05)。2组均未发现明显不良反应。结论 ADMA可作为阳虚血瘀型3～4期慢性肾脏病患者肾功能损伤程度的预测因子。温阳活血法能明显改善患者肾功能及ADMA水平,安全性良好。AIM To explore the clinical effects of Warming Yang and Promoting Blood Circulation Method combined with conventional treatment on patients with stage 3-4 chronic kidney disease due to Yang Deficiency and Blood Stasis. METHODS Eighty patients were randomly divided into control group for 3-month conventional treatment and treatment group for 3-month treatment of Warming Yang and Promoting Blood Circulation Method( Zhenwu Decoction combined with Taohe Chengqi Decoction) on the basis of the conventional treatment,40 cases in each group. Subsequently,the investigation of correlations between asymmetric dimethylarginine( ADMA) and renal function indices by using Pearson analysis and observation of the clinical efficacy,renal function indices,adverse reactions in both groups were practiced. RESULTS The treatment group demonstrated significantly higher total effective rate than the control group( P<0. 05). Both groups shared significantly decreased post-treatment serum creatinine( Scr),blood urea nitrogen( BUN) and ADMA( P<0. 05),and markedly increased estimated glomerular filtration rate( eGFR)( P<0. 05),which was particularly obvious in the treatment group( P<0. 05). Positive correlations between Scr and ADMA,BUN and ADMA( P<0. 05),and a negative correlation between eGFR and ADMA( P < 0. 05) were all observed. No obvious adverse reactions were found in the two groups.CONCLUSION ADMA,the predictor of renal function damage degree in patients with stage 3-4 chronic kidney disease due to Yang Deficiency and Blood Stasis demonstrates obvious improvement of patients’ renal function managed by Warming Yang and Promoting Blood Circulation Method,and the good safety of the method.

关 键 词：温阳活血法 常规治疗 3~4 期慢性肾脏病 阳虚血瘀型 

分 类 号：R287[医药卫生—中药学]