重组人脑利钠肽辅助治疗老年心力衰竭的疗效及其对心功能指标的影响  

Efficacy of adjuvant therapy using recombinant human brain natriuretic peptide for elderly patients with heart failure and its effects on cardiac function indicators

作　　者：于安石[1] YU An-shi(The First Department of Cardiovascular Medicine,Shenyang Medical College Affiliated Central Hospital,Shenyang 110024,China)

机构地区：[1]沈阳医学院附属中心医院循环内一科,辽宁省沈阳市110024

出　　处：《广西医学》2018年第24期2914-2916,2920,共4页Guangxi Medical Journal

摘　　要：目的观察重组人脑利钠肽辅助治疗老年心力衰竭的疗效及其对心功能指标的影响。方法将老年心力衰竭患者100例随机分为观察组与对照组,每组50例。两组均予常规治疗,在此基础上对照组静脉泵注硝酸甘油,观察组静脉推注重组人脑利钠肽,均连续治疗1周。比较两组患者的血清脑利钠肽和肌酐水平、心功能指标及疗效。结果治疗后,两组患者血清脑利钠肽和肌酐水平均较治疗前下降,且观察组患者下降更明显(均P <0. 05);两组患者左心室收缩末期内径、左心室舒张末期内径均较治疗前下降,左心室射血分数、每搏输出量均较治疗前增加,且观察组患者上述指标改善均比对照组明显(均P <0. 05);观察组患者疗效优于对照组(P <0. 05)。结论与硝酸甘油相比,重组人脑利钠肽辅助治疗老年心力衰竭患者,能更好地改善脑利钠肽、血肌酐水平,降低左心室收缩末期内径,增加左心室射血分数,提高疗效。Objective To observe the efficacy of adjuvant therapy using recombinant human brain natriuretic peptide for elderly patients with heart failure and its effects on cardiac function indicators.Methods A total of 100 elderly patients with heart failure were randomly divided into observation group and control group,with 50 cases in each group.On the basis of conventional treatment performed in the two groups,the control group received nitroglycerin by intravenous pumping,the observation group were given recombinant human brain natriuretic peptide by intravenous injection,and both groups were treated for one week.The levels of serum brain natriuretic peptide and creatinine,cardiac function indicators,and efficacy were compared between the two groups.Results After treatment,the levels of serum brain natriuretic peptide and creatinine decreased compared with those before treatment,and the decline in the observation group was more significant(all P<0.05);the left ventricular end-systolic diameter and left ventricular end-diastolic diameter decreased,while the left ventricular ejection fraction and stroke volume increased in both groups compared with those before treatment,and the observation group had a more obvious improvement in the indicators above compared to the control group(all P<0.05);the efficacy of the observation group was superior to that of the control group(P<0.05).Conclusion Compare with nitroglycerin,recombinant human brain natriuretic peptide,an adjuvant therapy for elderly patients with heart failure,can better modulate the levels of brain natriuretic peptide and serum creatinine,decrease left ventricular end-systolic diameter,increase left ventricular ejection fraction,and improve efficacy.

关 键 词：重组人脑利钠肽 老年人 心力衰竭 心功能 辅助治疗 

分 类 号：R541.6[医药卫生—心血管疾病]