对氯甲苯催化氧化制备对氯苯甲醛的研究进展  

Research progress on the preparation of p-chlorobenzaldehyde by catalytic oxidation of p-chlorotoluene

作　　者：谢军 张腾 陈浪 尹双凤[1] XIE Jun;ZHANG Teng;CHEN Lang;YIN Shuangfeng(State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering,HunanUniversity,Changsha 410082,Hunan,China)

机构地区：[1]湖南大学化学化工学院化学生物传感与计量学国家重点实验室,湖南长沙410082

出　　处：《化工进展》2019年第1期304-314,共11页Chemical Industry and Engineering Progress

基　　金：国家自然科学基金(21476065;21671062;21725602)

摘　　要：对氯苯甲醛是一种广泛用于医药、农药和染料的精细化工中间体,发展其绿色合成工艺极具挑战性和重大意义。本文较为系统地综述了催化氧化对氯甲苯为对氯苯甲醛的制备方法,重点阐述了H_2O_2氧化法、空气/氧气氧化法、电解氧化法和仿生催化氧化法的工艺条件,比较了间接电氧化合成方法中的各种金属媒质,讨论了各种制备方法的优缺点,分析了其相应的合成方法在工业开发上的可行性及存在的问题。此外,简要介绍了利用光催化法选择性氧化对氯甲苯合成对氯苯甲醛的方法。通过对几种合成方法的比较,指出以H_2O_2和分子氧为氧化剂液相催化氧化对氯甲苯来合成对氯苯甲醛是较为经济、环保的合成方法,电解氧化法和仿生催化氧化法将为对氯苯甲醛制备提供另一条新型技术途径。p-Chlorobenzaldehyde is an intermediate for many fine chemicals and it is widely used in the production of pharmaceuticals,agricultural chemicals,and dyes.It is significant but also very challenging to develop a green process for the catalytic synthesis of p-chlorobenzaldehyde.Herein synthesis of pchlorobenzaldehyde by catalytic oxidation of p-chlorotoluene was reviewed.Emphasis was put on the oxidation of p-chlorotoluene with H2O2,air/O2 or electro-oxidation,and biomimetic catalytic method.The advantages and disadvantages of these methods were described systematically,and the feasibility and existing problems in their industrial development were pointed out.In addition,the selective oxidation of p-chlorobenzene to p-chlorobenzaldehyde by photocatalysis was also introduced.After comparison of different synthesis methods,we point out that the liquid phase oxidation of p-chlorobenzene by using H2O2 and molecular oxygen as oxidant shows good industrial application prospect.Meanwhile,the electrooxidation and biomimetic catalytic oxidation will provide new techniques for the preparation of pchlorobenzaldehyde.

关 键 词：催化 氧化 选择性 对氯甲苯 对氯苯甲醛 

分 类 号：O643.3[理学—物理化学]