武汉市某医院就诊患者丙型肝炎病毒抗体与基因分型结果分析  

Analysis of Hepatitis C genotyping and Hepatitis C Virus antibody in patients in a hospital in Wuhan

作　　者：徐鲁 冯家立 章莉莎[1] XU Lu;FENG Jia-li;ZHANG Li-sha(Department of Laboratory Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei,430022,China)

机构地区：[1]华中科技大学同济医学院附属同济医院体检中心,湖北武汉430022 [2]华中科技大学同济医学院附属同济医院检验科

出　　处：《中西医结合肝病杂志》2018年第6期366-369,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:回顾性分析2017年武汉市某三甲医院就诊患者丙型肝炎病毒抗体及丙肝病毒基因分型结果,为丙型肝炎病毒的防治提供依据。方法:收集2017年1月至2017年12月在武汉市某三甲医院检验科进行丙型肝炎抗体检测和丙型肝炎病毒基因分型检测的患者资料,分析丙型肝炎抗体阳性率与年龄及性别的关系、丙型肝炎病毒抗体阳性患者在各科室的分布情况、丙型肝炎病毒基因型在接受检测的患者中的构成情况。结果:各年龄组之间丙型肝炎病毒抗体阳性率差异有统计学意义(χ2=354. 869,P <0. 05),60岁～70岁人群阳性率最高;不同性别人群丙型肝炎病毒抗体阳性率差异有统计学意义(χ2=12. 304,P <0. 05),女性阳性率高于男性;丙型肝炎病毒抗体阳性患者在各科室中的分布差异有统计学意义(χ2=342. 622,P <0. 05),感染科和肝脏外科阳性率最高;丙型肝炎基因分型以1b型和2a为主,占到受检人群90%以上。结论:1957年～1967年出生人群应该作为丙型肝炎病毒抗体的重点筛查对象,临床各科室中,部分科室阳性率明显高于其他科室,这些科室的医护人员应当更加注意个人防护措施,以防职业暴露的发生。在确定丙型肝炎治疗方案前进行基因分型的患者比例并不高,我们应该推广HCV治疗前的基因分型检测。Objective:To retrospectively analyze the genotyping results of hepatitis c virus genotyping and hepatitis c virus antibody(anti-HCV)in a tertiary hospital in Wuhan,providing basis for the prevention and treatment of hepatitis c virus.Methods:Collect data of patients who have conducted antibody test and HCV genotyping test between January 2017 and December 2017 in the clinical laboratory of the hospital and analysis the relations of HCV antibody positive rate,age,gender,the distribution of patients with hepatitis C antibody positive in each department,constituents of hepatitis c virus(HCV)genotypes in patients being tested.Results:The differences of positive rate of HCV antibody between each age group were statistically significant(χ^2=354.869,P<0.05).The positive rate is highest among people aged between 60 and 70 years old.At the same time,the difference of the positive rate of people of different genders were also statistically significant.The rate of female patients was higher than that of male patients.The rate difference of distribution of different department was statistically significant(χ^2=342.622,P<0.05).rate of positive of antibody of different gender group difference was statistically significant(χ^2=12.304,P<0.05).The rate of the Infection Department and Liver Surgery Department was the highes.Meanwhile,the majority of genotyping was 1b and 2a,accounting for more than 90%of the tested groups.Conclusion:People who are born during 1957 to 1967 should be the focus of each hepatitis c antibody screening.In each clinical department,the positive rate of some departments were significantly higher than the other departments so medical personnel of these department should pay more attention to their personal protective measures in order to prevent the occurrence of occupational exposure.The proportion of patients who receive genotyping tests before the therapeutic measures are decided is not large,thus promote genotyping test before HCV treatment should be promoted.

关 键 词：丙型肝炎病毒 丙型肝炎抗体 基因分型 流行病学 

分 类 号：R446.6[医药卫生—诊断学] R512.63[医药卫生—临床医学]