笼养食蟹猴攻击-屈服行为下的自然抑郁模型探究  

Investigation of natural depression model under the attack-yield behavior of caged cynomolgus monkeys

作　　者：李炜[1,2] 吴青原 连斌 杨迅 张建国 屈超华 何勇 谢鹏 LI Wei;WU Qing-yuan;LIAN Bin;YANG Xun;ZHANG Jian-guo;QU Chao-hua;HE Yong;XIE Peng(Department of Neurology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of Neurology,Army Medical Center of PLA,Chongqing 400042,China;Department of Neurology,Chongqing Three Gorges Central Hospital,Chongqing 404000,China)

机构地区：[1]重庆医科大学附属第一医院神经内科,重庆400016 [2]陆军特色医疗中心神经内科,重庆400042 [3]重庆三峡中心医院神经内科,重庆404000

出　　处：《上海交通大学学报（医学版）》2018年第12期1408-1413,共6页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家重点基础研究发展计划("973"计划)(2017YFA0505700)~~

摘　　要：目的·探讨食蟹猴(Macaca fascicularis)的自然抑郁模型是否与攻击-屈服行为有关。方法·模拟野生环境,组建2个食蟹猴群体(G_1和G_2),分别由19和14只食蟹猴个体组成。人为观察法记录2个群体内攻击-屈服行为的有效次数,分析并利用攻击-屈服行为矩阵,分别计算出每个个体在群体中David得分(David's score,DS)。根据个体DS得分的高低,将每个群体划分为攻击组和屈服组;焦点观察法记录个体7个时段行为变化,并对所观察到的11类行为进行统计分析。结果·组建群体后食蟹猴发生了较为激烈的冲突,2个群体分别记录到1 122和1 409次攻击-屈服行为。每个群体的攻击组和屈服组的日常行为分析结果显示,2个群体的不同组别在焦虑行为(t_1=-4.053,P_1=0.005;t_2=-3.041;P_2=0.012)、冲突行为(t_1=8.478,P_1=0.018;t_2=7.651;P_2=0.002)、抑郁行为(t_1=-3.691,P_1=0.006;t_2=-2.431;P_2=0.045)、运动行为(t_1=9.639,P_1=0.007;t_2=3.568;P_2=0.002)上的差异均有统计学意义。结论·笼养食蟹猴的自然抑郁模型是一种由群体攻击-屈服行为所引发的社会挫败模型。Objective · To investigate the natural depression model of Macaca fascicularis induced by submissive-aggressive behaviors. Methods · In a simulated wild environment, two Macaca fascicuaris groups(G1 and G2) were respectively established. The two groups consisted of 19 and 14 Macaca fascicularis respectively. The effective frequency of each group’s submissive-aggressive behaviors was observed and recorded, the matrix of submissiveaggressive behaviors was analyzed, each individual of the group was calculated separately by David’s score(DS), according to the level of individual DS,each group was divided into attack group and yield group; the behavior changes of each individual in 7 periods were recorded by the focus observation and the correlation analysis of 11 different behaviors was carried out. Results · After the formation of these groups, there was fierce conflict between the cynomolgus monkeys. 1 122 and 1 409 submissive-aggressive behaviors were recorded in the two groups respectively. In the submissive-aggressive behavior matrix, the differences between high and low DS in anxiety behavior(t1=-4.053, P1=0.005; t2=-3.041, P2=0.012), conflict behavior(t1=8.478,P1,=0.018; t2=7.651, P2=0.002), depression behavior(t1=-3.691, P1,=0.006; t2=-2.431, P2=0.045) and exercise behavior(t1=9.639, P1,=0.007; t2=3.568;P2=0.002) were statistically significant. Conclusion · The natural depression model of caged Macaca fascicularis is a social defeat model induced by yield-attack behavior.

关 键 词：抑郁症 食蟹猴 攻击-屈服行为 David得分 社会挫败 

分 类 号：Q959.848[生物学—动物学]