可注射热致物理水凝胶的结构研究:半禿胶束及含疏水通道的逾渗胶束网络  

Structure Studies of Injectable Physical Thermogel:Semi-bald Micelle and Corresponding Percolated Micelle Network with Hydrophobic Channel

作　　者：江明[1] JIANG Ming(State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science,Fudan University, Shanghai 200438, China)

机构地区：[1]聚合物分子工程国家重点实验室,复旦大学高分子科学系,上海200438

出　　处：《功能高分子学报》2019年第1期1-4,共4页Journal of Functional Polymers

摘　　要：两亲性嵌段共聚物在选择性溶剂中可自组装形成胶束,但进一步发生凝胶化则并不寻常。部分聚乙二醇-聚酯嵌段共聚物-水体系随温度升高可以发生溶胶-凝胶转变,这是发展一种优异的可注射水凝胶材料的基础。该材料的应用前景引起了高度关注,然而,对于两亲性高分子-水体系具备怎样的分子参数条件才能呈现热致凝胶化这一关键问题则知之甚少,相应高分子物理方面基础科学研究的不足严重制约了该领域的发展。复旦大学丁建东团队长期致力于该类材料的研究,在推动该材料产业化的同时,深入研究其内在的软物质科学问题。最近,丁建东课题组对热致水凝胶的内在结构研究取得了创新性进展:他们综合运用理论与实验研究,提出了"半秃胶束"的概念,此胶束进一步缔合可形成具有疏水通道的逾渗胶束网络。他们阐明了新的物理凝胶化机理,为运用聚合物分子工程手段进行热致水凝胶的分子设计提供了重要的理论指导,并具有一定的普适意义。While many amphiphilic block copolymers can self-assemble into micelles in selective solvents,it is unusual to further form a physical gel.Some of block copolymers composed of poly(ethylene glycol)(PEG)and some polyesters undergo a sol-gel transition in water upon heating,which afford a potential class of new materials as an injectable hydrogel in biomedicine.While this system has been studied for about 20 years,it still remains at the stage of laboratory research today.A crucial bottleneck of its clinical application is the lack of a general guideline for molecular design,which needs a clear illustration of the internal structure and the mechanism of the thermogelling system.Recently,Prof.Ding’s group proposed a mechanism model at the molecular level to demonstrate the sol-gel transition of the thermogel.A new type of micelle,called semi-bald micelle,was first proposed as the precursor for thermogelling,and confirmed from both computer simulations and experiments.Besides,Prof.Ding’s group demonstrated that the thermogel structure was a percolated micelle network with hydrophobic channels evolved from the semi-bald micelles.This findings can not only explain the interesting thermogelling phenomenon,but also possess guidance of molecular design of this type of new materials.The proposed mechanism might also be stimulated to understand other responsive systems and corresponding self-assembly dynamics.

关 键 词：物理水凝胶 热致水凝胶 两亲性嵌段共聚物 半禿胶束 逾渗胶束网络 生物材料 

分 类 号：O63[理学—高分子化学]