活血潜阳方预防腹型肥胖性高血压病人早期心脏损害的临床疗效观察  

Clinical Observation on the Prevention of Early Cardiac Damage of Abdominal Obesity Hypertension by Huoxue Qianyang Decoction

作　　者：龙敏[1] 姚磊[1] 符德玉[1] 周训杰[1] 桂明泰[1] 李建华[1] 芦波[1] 韩亚楠[1] 舒婷[1] Long Min;Yao Lei;Fu Deyu;Zhou Xunjie;Gui Mingtai;Li Jianhua;Lu Bo;Han Ya′nan;Shu Ting(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院,上海200437

出　　处：《中西医结合心脑血管病杂志》2018年第24期3593-3596,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：上海市进一步加快中医药事业发展三年行动计划(2014-2016年)资助项目(No.ZY3-CCCX-3-3026);高等学校博士学科点专项科研基金项目(No.30133107110011);上海市岳阳中西医结合医院高血压重点专病专科

摘　　要：目的评价活血潜阳方预防腹型肥胖性高血压病人早期心脏损害的临床疗效。方法收集符合纳入和排除标准的70例病人,随机分为治疗组和对照组,各35例,进行为期3个月的随访观察,并对其临床结果进行统计分析。结果经过3个月治疗后,治疗组和对照组体重指数、血脂比较差异无统计学意义(P>0.05);治疗组中医证候积分、腹围、B型尿钠肽、室间隔厚度、血压左心室质量指数及临床疗效明显优于对照组(P <0.05)。治疗组未发现安全指标异常病例。结论活血潜阳方联合西药治疗可延缓腹型肥胖性高血压病人早期心脏损害,临床疗效明显优于单纯西药,且无明显毒副作用。Objective To evaluate the clinical efficacy of Huoxue Qianyang decoction(HQD)in preventing abdominal obesity and early hypertensive cardiac damage.Methods Seventy patients were randomly divided into two groups:control group(n=35)treated with routine treatment,and treatment group(n=35)treated with routine treatment and HQD.After 3 months,the clinical data and results of statistical analysis were observed.Results After 3 months of treatment,there was no significant difference in body mass index and blood lipid between the treatment group and the control group(P>0.05).The traditional Chinese medicine(TCM)syndrome score,abdominal circumference,type B natriuretic peptide,interventricular septum thickness,blood pressure,left ventricular mass index and clinical efficacy in treatment group were significantly better than that in the control group(P<0.05).No abnormal patient safety indicator was found in the treatment group.Conclusion The clinical efficacy of HQD and western medicine for delaying cardiac damage in abdominal obesity hypertension was significantly better than that of western medicine,and there was no obvious side effects.

关 键 词：高血压 腹型肥胖 活血潜阳方 体重指数 血脂 中医证候积分 腹围 B型尿钠肽 室间隔厚度 左心室质量指数 

分 类 号：R544.1[医药卫生—心血管疾病] R255.3[医药卫生—内科学]