机构地区:[1]四川省宜宾市第二人民医院检验科,四川宜宾644000
出 处:《中国医药导报》2019年第1期153-156,161,共5页China Medical Herald
基 金:四川省宜宾市科技计划项目(2015SF022)
摘 要:目的探讨急性心肌梗死(AMI)患者外周血Toll样受体4(TLR4)、血清肿瘤坏死因子-α(TNF-α)变化及临床意义。方法选择2015年6月~2018年3月四川省宜宾市第二人民医院收治的103例AMI患者作为研究组,根据并发症情况分为无并发症组(29例)、并发症组(55例)和死亡组(19例);根据治疗效果,患者分为治愈组(43例)、好转组(40例)和无效组(20例)。另外选择同期51例参加体检的胸痛患者作为对照组。对比研究组和对照组受试者外周血TLR4、血清TNF-α及冠脉病变(Gensini)评分,同时观察外周血TLR4、血清TNF-α及Gensini评分对AMI亚组及疗效的影响,另外分析外周血TLR4与血清TNF-α的相关性,及两者与Gensini评分的相关性。结果研究组患者外周血TLR4、血清TNF-α及Gensini评分均明显高于对照组(P <0.05);并发症组和死亡组患者外周血TLR4、血清TNF-α及Gensini评分明显高于无并发症组,死亡组患者外周血TLR4、血清TNF-α及Gensini评分显著高于并发症组,差异均有统计学意义(P <0.05);与治愈组比较,好转组和无效组患者外周血TLR4、血清TNF-α及Gensini评分均明显升高,无效组患者外周血TLR4、血清TNF-α及Gensini评分均显著高于好转组,差异均具有统计学意义(P <0.05);AMI患者外周血TLR4与血清TNF-α及Gensini评分呈正相关(r=0.751、0.703,P <0.05),同时血清TNF-α与Gensini评分呈正相关(r=0.729,P <0.05)。结论 TLR4和TNF-α参与AMI的发生及发展,还可以评估临床治疗效果,为临床治疗AMI提供新的治疗靶点。Objective To investigate the changes of toll-like receptor 4(TLR4)and trmor necrosis factor-α(TNF-α)in peripheral blood of patients with acute myocardial infarction(AMI)and their clinical significance.Methods From June 2015 to March 2018,103 AMI patients admitted to Yibin Second People′s Hospital of Sichuan Province were selected as the research group.According to the complications,the patients were divided into uncomplicated group(29 cases),complication group(55 cases)and death group(19 cases).According to the treatment effect,the patients were divided into the cured group(43 cases),the improved group(40 cases)and the ineffective group(20 cases).In addition,51 patients with chest pain who participated in physical examination in the same period were selected as the control group.Meanwhile,the effects of TLR4,TNF-αand Gensini scores in peripheral blood of subjects in the study group and the control group on AMI subgroup and efficacy were observed.In addition,the correlation between TLR4 and serum TNF-αand Gensini scores in peripheral blood were analyzed.Results TLR4,TNF-αand Gensini scores in the peripheral blood of the study group were significantly higher than those of the control group(P<0.05);The scores of TLR4,TNF-αand Gensini in the peripheral blood of patients in the complication group and the death group were significantly higher than those in the non-complication group,and the scores of TLR4,TNF-αand Gensini in the peripheral blood of patients in the death group were significantly higher than those in the complication group,with statistically significant differences(P<0.05).Compared with the treatment group,the scores of TLR4,TNF-αand Gensini in peripheral blood of patients in the improved group and the ineffective group were significantly higher than those in the improved group(P<0.05).TLR4 in peripheral blood of AMI patients was positively correlated with serum TNF-αand Gensini score(r=0.751,0.703,P<0.05),while serum TNF-αwas positively correlated with Gensini score(r=0.729,P<0.05).Conclusio
关 键 词:急性心肌梗死 TOLL样受体4 肿瘤坏死因子-Α 预测价值
分 类 号:R542[医药卫生—心血管疾病]
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