青海地区肝囊性包虫病术后IL-11、TNF-a、iNOS的变化及乌司他丁干预作用的临床研究  

The changes of IL-11,TNF-a and iNOS after liver cystic hydatidosis surgery and the intervention of ulinastatin on patients in Qinghai Province

作　　者：阿吉德 柴金萍 王皓[1] 田青山[1] 王向前 杨金煜[1] Ajide;CHAI Jinping;WANG Hao;TIAN Qingshan;WANG Xiangqian;YANG Jinyu(Department of General Surgery,Qinghai Provincial People′s Hospital,Xining 810007,China)

机构地区：[1]青海省人民医院普外科,西宁810007

出　　处：《新疆医科大学学报》2019年第1期111-115,119,共6页Journal of Xinjiang Medical University

基　　金：青海省2017年卫生计生课题指导性计划项目(2017-wjzdx-23)

摘　　要：目的观察青海地区肝囊性包虫病患者术后白介素-11(IL-11)、肿瘤坏死因子-a(TNF-a)、一氧化氮合成酶(iNOS)等细胞因子变化,并观察乌司他丁对肝包虫术后炎性因子及细胞因子的干预作用。方法选取2016年5月-2017年12月青海省人民医院收治的肝包虫病患者60例,根据术后有无使用乌司他丁分为对照组及乌司他丁干预组。所有患者于术前、术后1d、术后3d、术后5d及术后7d抽取外周静脉血,应用ELISA方法检测术前、术后1d、术后3d、术后5d及术后7d的IL-11、TNF-a、iNOS浓度。并比较乌司他丁干预组与对照组的以上指标的在不同时点浓度的变化趋势是否存在差异。结果乌司他丁干预组与对照组相比术前、术后1d及术后3dIL-11、TNF-a、iNOS差异无统计学意义(P>0.05),重复测量的单因素方差分析显示不同干预方法间IL-11、TNF-a、iNOS差异有统计学意义(P <0.05);相同干预方法的不同时间点比较,IL-11、TNF-a、iNOS差异有统计学意义(P <0.05);乌司他丁干预组与对照组的变化趋势(时间×组别)差异有统计学意义(P <0.05)。结论乌司他丁在抑制机体炎症因子IL-11及细胞因子TNF-a、iNOS方面有很好的效果。Objective To observe the changes of interleukin-11(IL-11),tumor necrosis factor-a(TNF-a)and inducible Nitric Oxide Synthase(iNOS)after liver cystic hydatidosis surgery and to observe the intervention effect of ulinastatin on patients′postoperative inflammatory factors and cell factors in Qinghai province.Methods 60 patients with liver cystic hydatidosis disease were selected in Qinghai Provincial People′s Hospital from May 2016 to December 2017.They were randomly divided into control group and ulinastatin intervention group.Peripheral venous blood were drawn from the patients of both groups and IL-11,TNF-a and iNOS were detected by ELISA method on 2 days before operation,1 day after operation,3 days after operation,5 days after operation,7 days after operation.The above indicators at different time points were compared between two groups.Results Compared with control group,there were no significant differences in IL-11,TNF-a,iNOS in ulinastatin intervention group before operation,1 day after operation and 3 days after operation(P>0.05).The IL-11,TNF-a,iNOS in ulinastatin intervention group compared with control group on 5 days after operation and 7 days after operation were statistically significant(P<0.05).The single factor variance analysis of repeated measurements showed that there were statistically differences in IL-11,TNF-a,iNOS between two groups(P<0.05).In the same group,there were statistically differences in IL-11,TNF-a,iNOS between different time points(P<0.05).The change trend(time×group)of IL-11,TNF-a,iNOS in the ulinastatin intervention group compared with the control group were statistically significant(P<0.05).Conclusion It is suggested that ulinastatin has good effects on inhibiting the inflammatory factor IL-11 and cell factors TNF-a,iNOS.

关 键 词：肝囊性包虫病 乌司他丁 炎性因子 细胞因子 中度海拔 

分 类 号：R657.6[医药卫生—外科学]