串联反应合成2-氨基-3,5-二氰基-4H-吡喃衍生物（英文）  

Synthesis of 2-amino-3,5-dicyano-4H-pyran derivatives by cascade reaction

作　　者：尹晓刚[1,2] 吴小云 付海[2] 班大明 陈卓 龚维[2] YIN Xiaogang;WU Xiaoyun;FU Hai;BAN Daming;CHEN Zhuo;GONG Wei(School of Chemistry and Materials Science,Guizhou Normal University,Guiyang,Guizhou 550001,China;Key Laboratory of Functional Materials Chemistry of Guizhou Province,Guizhou Normal University,Guiyang,Guizhou 550001,China)

机构地区：[1]贵州师范大学化学与材料科学学院,贵州贵阳550001 [2]贵州省功能材料化学重点实验室,贵州贵阳550001

出　　处：《贵州师范大学学报（自然科学版）》2019年第1期40-46,共7页Journal of Guizhou Normal University：Natural Sciences

基　　金：贵州省科技厅联合基金(黔科合LH字[2016]7218)~~

摘　　要：通过以丙二腈和氰基查尔酮作为原料,使用串联反应开发了一种2-氨基-3,5-二氰基-4H-吡喃衍生物的快速且高效的方法。筛选了催化剂、溶剂、反应时间、温度以及原料摩尔浓度对产率的影响。该方法具有产率高、反应条件温和以及催化剂廉价易得的优点。A rapidly and highly efficient protocol for the synthesis of pharmaceutically interesting functionalized 2-amino-3,5-dicyano-4 H-pyran derivatives had been developed by using commercially available and very cheap zinc acetate as the catalyst malononitrile and cyanochalcone as raw materials.The influence of catalysts,solvents,reaction time and temperature,and molarity of the raw materials on yields were studied.The major advantages of this methodology were excellent yield,low temperature,and the use of an inexpensive catalyst.

关 键 词：串联反应 吡喃衍生物 丙二腈 杂环化合物 

分 类 号：O626.41[理学—有机化学]