新辅助放射治疗和化学治疗联合手术治疗晚期子宫内膜癌效果观察  

Effect of neoadjuvant radiotherapy and chemotherapy combined with surgery in the treatment of advanced endometrial carcinoma

作　　者：赵彩琴[1] 赵宝祥[2] ZHAO Cai-qin;ZHAO Bao-xiang(Department of Reproductive Medicine and Gynecology,the First People's Hospital of Nanyang City,Nanyang 473000,Henan Province,China;Department of Clinical Laboratory,the Second Hospital of Qinhuangdao,Qinhuangdao 066000,Hebei Province,China)

机构地区：[1]南阳市第一人民医院生殖妇科,河南南阳473000 [2]秦皇岛市第二医院检验科,河北秦皇岛066000

出　　处：《新乡医学院学报》2019年第1期74-76,共3页Journal of Xinxiang Medical University

摘　　要：目的探讨新辅助放射治疗和化学治疗联合手术治疗晚期子宫内膜癌的临床效果。方法选择2013年2月至2015年2月南阳市第一人民医院收治的98例晚期子宫内膜癌患者为研究对象,按照治疗方案分为对照组和观察组,每组49例。对照组患者给予手术治疗,观察组患者给予新辅助放射治疗、化学治疗联合手术治疗,2组患者术后均给予规范化学治疗。分别于治疗前及术后3个月采用世界卫生组织生存质量测定量表评估2组患者的生活质量;所有患者术后随访3 a,统计3 a生存率和无瘤生存时间。结果治疗前观察组和对照组患者生活质量评分分别为39. 75±5. 16、39. 19±5. 84,术后3个月观察组和对照组患者生活质量评分分别为60. 95±3. 67、51. 46±4. 29;治疗前2组患者生活质量评分比较差异无统计学意义(t=0. 503,P> 0. 05); 2组患者术后3个月生活质量评分高于治疗前(t=21. 225、11. 853,P <0. 05);术后3个月,观察组患者生活质量评分高于对照组(t=9. 587,P <0. 05)。观察组和对照组患者术后3 a生存率分别为63. 27%(31/49)、46. 94%(23/49),2组患者术后3 a生存率比较差异无统计学意义(χ~2=2. 640,P> 0. 05)。观察组和对照组患者无瘤生存时间分别为(24. 19±3. 18)、(20. 06±2. 19)个月,观察组患者无瘤生存时间长于对照组(t=7. 491,P <0. 05)。结论新辅助放射治疗和化学治疗联合手术治疗可以显著延长晚期子宫内膜癌患者的无瘤生存时间,提高患者的生活质量。Objective To investigate the clinical effect of neoadjuvant radiotherapy and chemotherapy combined with surgery in the treatment of advanced endometrial carcinoma.Methods Ninety-eight patients with advanced endometrial carcinoma in the First People's Hospital of Nanyang City from February 2013 to February 2015 were selected as the subjects.The patients were divided into control group and observation group according to the treatment plan,forty-nine cases in each group.The patients in the control group were treated with surgery alone,while the patients in the observation group were treated with neo adjuvant radiotherapy and chemotherapy combined with surgery.The patients in the two groups were treated with standardized chemotherapy after operation.The quality of life of the patients in the two groups was assessed by World Health Organization quality of life scale before treatment and 3 months after operation.All patients were followed up for 3 years,and the 3-year survival rate and tumor-free survival time were counted.Results The score of quality of life in the observation group and the control group was 39.75±5.16 and 39.19±5.84 respectively before treatment.The score of quality of life in the observation group and the control group was 60.95±3.67 and 51.46±4.29,respectively at three months after operation.There was no significant difference in the score of quality of life between the two groups before treatment (t=0.503,P>0.05).The score of quality of life at 3 months after operation was higher than that before treatment in the two groups (t=21.225,11.853;P<0.05).The score of quality of life in the observation group was higher than that in the control group at three months after operation (t=9.587,P<0.05).The 3-year survival rate in the observation group and the control group was 63.27%(31/49) and 46.94%(23/49),respectively.There was no significant difference in the 3-year survival rate between the two groups (χ^2=2.640,P>0.05).The tumor-free survival time in the observation group and the control group was

关 键 词：子宫内膜癌 新辅助放射治疗 新辅助化学治疗 手术治疗 

分 类 号：R711[医药卫生—妇产科学]