人脐带间充质干细胞移植治疗脊髓损伤的研究进展  

Progress of human umbilical cord mesenchymal stem cell transplantation for spinal cord injury

作　　者：陈奇[1] 孙翊夫[1] 吕晓霞[2] 张福强 顾锐[1] 高旭 邵立伟 姜金兰[1,3] Chen Qi;Sun Yifu;Lyu Xiaoxia;Zhang Fuqiang;Gu Rui;Gao Xu;Shao Liwei;Jiang Jinlan(Department of Orthopedic Surgery,China-Japan Union Hospital,Jilin University,Changchun 130033,China;Central Laboratory of Shandong Provincial Hospital,Jinan 250021,China;Scientific Research Center,China-Japan Union Hospital,Jilin University,Changchun 130033,China)

机构地区：[1]吉林大学中日联谊医院骨科,长春130033 [2]山东大学附属省立医院中心实验室,济南250021 [3]吉林大学中日联谊医院科学研究中心,长春130033

出　　处：《中华细胞与干细胞杂志（电子版）》2018年第4期229-233,共5页Chinese Journal of Cell and Stem Cell（Electronic Edition）

摘　　要：脊髓损伤(SCI)由于复杂病理生理和神经修复再生困难,至今仍旧是难以攻克的医学难题,而干细胞因其神经再生和神经保护特性被认为是治疗SCI最有希望的方法。其中人脐带间充质干细胞(HUC-MSCs)近年培养分化方法不断改进、神经修复机制初步阐明,联合移植等综合治疗方案也不断实践,使HUC-MSCs移植治疗效果提高。另外关于HUC-MSCs治疗SCI的临床试验逐渐开展,术后患者神经功能恢复改善且无严重并发症出现,表明干细胞移植应用于人体是安全有效的。本文就HUC-MSCs治疗SCI的研究状况及进展进行综述。Spinal cord injury(SCI)is still a difficult problem because of its complex pathophysiology.Stem cell transplantation are considered as the most promising treatment for SCI due to their nerve regeneration and neuroprotective effect.The methods of human umbilical cord mesenchymal stem cell(HUC-MSC)culture and differentiation have been improved.Moreover,the mechanism of neural repair has been preliminarily clarified.Combination therapy and other comprehensive treatment have improved the effect of stem cell transplantation.In addition,several clinical trials on stem cell therapy are on the way.HUC-MSCs transplantation can significantly improve the neurological function of patients without serious complications,indicating that stem cell therapy is safe and effective in human.This review summarizes and discusses recent advances on HUC-MSCs therapy for SCI.

关 键 词：脊髓损伤 人脐带间充质干细胞 细胞移植 联合治疗 

分 类 号：R651.2[医药卫生—外科学]