扶正中药在乳腺癌新辅助治疗中的意义  

Significance of Fuzheng Chinese Medicine Combined with Neoadjuvant Chemotherapy in Breast Cancer

作　　者：盛佳钰[1] 刘钰 严兆霞 江科[1] SHENG Jiayu;LIU Yu;YAN Zhaoxia;JIANG Ke(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院乳腺病科,上海200437

出　　处：《云南中医学院学报》2018年第3期47-50,54,共5页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：上海市卫计委科研项目(201540234;2018LQ020);上海市科委科研计划项目(17401935300)

摘　　要：目的观察扶正中药联合新辅助化疗在乳腺癌中的临床疗效。方法随机将可手术乳腺癌分成单纯化疗组及中药联合化疗组,观察2组间的临床及病理疗效,及P-糖蛋白(P-gp)在2组间的表达差异。结果 102例患者中,单纯化疗组与联合组在临床疗效上无差别,但在病理疗效差别有统计学意义,P-gp阳性患者病理缓解不明显,联合组经新辅助治疗后P-gp的转阳率较单纯化疗组少,差异有统计学意义。结论 P-gp的表达对于化疗疗效具有一定的预测作用,扶正中药可能通过P-gp途径,有逆转化疗耐药的作用,同时提高了新辅助化疗的病理缓解率。Objective To investigate the effect of Fuzheng Chinese medicine combined with neoadjuvant chemotherapy in breast cancer.Methods We randomized operable breast cancer into chemotherapy group and Chinese medicine combined with chemotherapy group.The clinical and pathological effects,and expression of P-glycoprotein(Pgp)were observed between two groups.Results There was no difference in clinical effect between two groups.However,statistical difference existed in pathological effect.No significant pathological response was observed in Pgp-positive patients.The positive rates of Pgp was less in the combined group than that in the chemotherapy group.Statistical significance existed between two groups.Conclusion The expression of Pgp has a predictive effect on chemotherapy effect.Fuzheng Chinese medicine may reverse chemotherapy resistance through Pgp pathway.And it also improves the pathological response rate of neoadjuvant chemotherapy.

关 键 词：乳腺肿瘤 新辅助化疗 P-糖蛋白 扶正中药 

分 类 号：R273[医药卫生—中西医结合]