神经源性营养因子3对早期急性心肌梗死的诊断作用  

Value of Neurotrophin-3 in early diagnosis of acute myocardial infarction

作　　者：刘华春 杨根 胡巧 LIU Huachun;YANG Gen;HU Qiao(Department of Intensive Care Unit,Liangjiang People’s Hospital of Guangdong Medical University,Zhanjiang 524400,China)

机构地区：[1]广东医科大学附属廉江市人民医院重症医学科,广东湛江524400

出　　处：《分子影像学杂志》2019年第1期108-111,共4页Journal of Molecular Imaging

摘　　要：目的研究神经源性营养因子3(NT-3)对早期急性心肌梗死(AMI)的诊断价值和意义。方法选取胸痛疑似心肌梗死患者90例,其中确诊AMI患者组45例为观察组,胸痛但检查不是AMI者45例为对照组,分别检测两组患者在胸痛发病<3 h、3～6h及6～12 h的血清NT3、CK-MB和cTnT水平;比较在AMI发病<3 h、3～6 h及6～12 h时NT-3、CK-MB和c TnT诊断AMI时的敏感性及特异性。结果对照组血清NT-3、CK-MB和c TnT没有明显变化(P>0.05)。在AMI组患者中,血清NT-3在AMI后<3 h即显著升高(P<0.01),在3～6 h及6～12 h升高更为明显(P<0.01);血清CK-MB在AMI发病6 h内无明显升高(P>0.05),在6～12 h时才升高(P<0.01);血清cTnT在AMI<3 h无明显增加(P>0.05),3～6 h和6～12 h显著升高(P<0.01)。在AMI发病<3 h、3～6 h时,血清NT-3的敏感性及特异性高于CK-MB、cTnT,血清NT-3在AMI发生6～12 h的敏感性及特异性与c TnT相近,且NT-3和c TnT的敏感性和特异性均高于CK-MB。结论血清NT-3在AMI早期诊断中敏感性和特异性可能优于传统心肌标记物,可以作为一种新的AMI的早期诊断指标。Objective To explore the value of the biochemical marker Neurotrophin-3(NT-3)in early diagnosis of acute myocardial infarction(AMI).Methods A total of 90 chest pain patients with suspected myocardial infarction were selected.45 patients with confirmed AMI were selected as the observation group,and 45 cases of chest pain but not AMI were selected as the control group.Serum NT-3,CK-MB and cTnT levels were measured in the two groups at<3 h,3-6 h and 6-12 h after chest pain.The sensitivity and specificity of NT-3,CK-MB and cTnT in the diagnosis of AMI were compared with<3 h,3-6 h and 6-12 h after AMI.Results There were no significant changes in serum NT-3,CK-MB and cTnT in the control group(P>0.05).Serum NT-3 in patients with AMI was significantly increased at<3 h after AMI(P<0.01),and increased significantly at 3-6 h and 6-12 h(P<0.01).Serum CK-MB in patients with AMI did not increase significantly within 6 h after AMI(P>0.05),but increased at 6-12 h(P<0.01).Serum cTnT did not increase significantly at<3 h after AMI(P>0.05),and increased significantly at 3-6 h and 6-12 h after AMI(P<0.01).The sensitivity and specificity of serum NT-3 were higher than CK-MB and cTnT at<3 h and 3-6 h after AMI.The sensitivity and specificity of serum NT-3 at 6-12 h after AMI were similar to those of cTnT,and the sensitivity and specificity of NT-3 and cTnT were higher than those of CK-MB.Conclusion The sensitivity and specificity of serum NT-3 in early diagnosis of AMI may be superior to traditional myocardial markers.It can be used as a new early diagnostic indicator of AMI.

关 键 词：急性心肌梗死 神经源性营养因子3 肌酸激酶同工酶 心肌钙蛋白T 

分 类 号：R542.22[医药卫生—心血管疾病]