小檗碱对口服降糖药糖尿病患者的胃肠激素及肠道菌群的影响  

Effect of Berberine on Gastrointestinal Hormones and Intestinal Flora in DM Patients Intervened by Antidiabetic Agents

作　　者：熊红萍[1] 徐静[1] 周强[1] 吴埼淇 甘国翔 陈忠山 XIONG Hongping;XU Jing;ZHOU Qiang;WU Qiqi;GAN Guoxiang;CHEN Zhongshan(Fuzhou Second Hospital Affiliated to Xiamen University,Fuzhou 350007,China;Xiamen University,Xiamen 361102,China;Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China)

机构地区：[1]厦门大学附属福州市第二医院,福建福州350007 [2]厦门大学,福建厦门361102 [3]福建中医药大学,福建福州350122

出　　处：《中医药学报》2019年第1期64-68,共5页Acta Chinese Medicine and Pharmacology

基　　金：福州市卫计委创新团队课题(2015-S-wt2);福建省中青年骨干科技计划项目(2015-ZQN-JC-37)

摘　　要：目的:探讨盐酸小檗碱对2型糖尿病(T2DM)胃泌素(GAS)、胰高血糖素(GLC)及肠道菌群的影响。方法:以25例口服降糖药治疗的T2DM患者为治疗组,对照组选取健康人群10例。T2DM患者常规治疗,同时给予盐酸小檗碱500 mg,每日3次,连续12周。分别于0、4、8、12周检测血糖、GAS、GLC,于0、12周采集清晨空腹粪便进行粪便菌群培养。结果:治疗组治疗后FPG及餐后1hPG有不同程度的下降(P<0.05)。治疗前后治疗组GAS、GLC水平均明显高于对照组(P<0.05)。治疗组治疗后GAS水平持续升高(P<0.05)。治疗后治疗组厚壁菌门明显低于治疗前(P<0.05)。治疗后治疗组大肠杆菌属明显高于治疗前(P<0.05)。治疗前治疗组柔嫩梭菌属明显低于对照组(P<0.05)。治疗后治疗组厚壁菌门明显低于对照组(P<0.01)。治疗前后治疗组拟杆菌明显低于对照组(P<0.05)。结论:小檗碱有助于改善T2DM患者胃肠激素、肠道菌群失调现象,改善糖代谢紊乱。Objective:To explore the effect of Berberine on gastrin(GAS),glugacon(GLC),and intestinal flora in patients with Type 2 diabetes mellitus(T2DM).Methods:25 cases of T2DM intervened with antidiabetic agents were included into the treatment group;whereas 10 healthy people were included into the control group.The treatment group was given Berberine(500 mg,tid)for 12 consecutive weeks on the basis of routine medication.The levels of blood glucose(BG),GAS,and GLC were tested during different periods,i.e.week 0,week 4,week 8 and week 12 respectively.In addition,on week 0 and week 12,the patients'faeces were collected for fecal flora culture.Results:After the treatment,FBG and 1hBG showed decrease to different extents in the treatment group(P<0.05).The levels of GAS and GLC before and after the treatment were both significantly higher in the treatment group than those in the control group(P<0.05).GAS level remained continuous increase after the treatment in the treatment group(P<0.05);Phylum Firmicutes was significantly decreased and colibacillus was signficantly increased after the treatment compared to those before the treatment in the treatment group(P<0.05).Clostridium leptum was lower in the treatment group than that in the control group before the treatment(P<0.05).Phylum Firmicutes was lower in the treatment group than that in the control group after the treatment(P<0.01).Bacteroides was lower in the treatment group than that in the control group before and after the treatment(P<0.05).Conclusion:Berberine can help improve the disequilibrium of gastrointestinal hormone and intestinal flora,it can also improve glycometabolic disorder.

关 键 词：糖尿病 胃泌素 胰高血糖素 小檗碱 肠道菌群 

分 类 号：R587.1[医药卫生—内分泌]