一例成人流感相关脑炎及文献回顾  

Influenza-associated Encephalitis in Adult: a case report and literature review

作　　者：梅雪[1] 代发辉 王蔚 吴凡 黄琴[1] 凌云[1] 卢洪洲[1] MEI Xue;DAI Fa-hui;WANG Wei;WU Fan;HUANG Qin;LING Yun;LU Hong-zhou(Department of infectious disease,Shanghai Public Health Clinical Center,Shanghai 201508,China;Department of Pathogen Diagnosis and Biosafety,Shanghai Public Health Clinical Center,Shanghai 201508,China)

机构地区：[1]上海市公共卫生临床中心感染科,上海201508 [2]上海市公共卫生临床中心病原体检测和生物安全部,上海201508

出　　处：《新发传染病电子杂志》2018年第3期146-149,共4页Electronic Journal of Emerging Infectious Diseases

基　　金：上海申康医院发展中心"促进市级医院临床技能与临床创新三年行动计划"项目(16CR1018A)

摘　　要：目的描述一例成人流感相关脑炎患者的临床表现、诊疗经过及该疾病相关文献回顾,旨在提高临床医师对本病的认识,尽早明确诊断并给予正确的治疗方法。方法分析上海市公共卫生临床中心2018年2月收治的1例流感相关脑炎患者的临床表现及诊疗经过,并结合国内外文献的回顾,进一步认识和学习该病的临床表现和诊疗进展。结果流感流行季,存在中枢神经系统感染的患者,需鉴别流感相关脑炎,脑脊液、血液、咽拭子等标本检测完善病原学(核酸检测)及免疫学依据有助于早期诊断流感相关脑炎。结论对于伴有神经系统症状的流感患者应当警惕流感脑炎的发生。易感人群建议每年预防性接种流感疫苗减少流感及其严重并发症的发生。Objective To describe the clinical manifestations, diagnosis and treatment of a case of adult influenza-associated encephalitis, and related literatures were reviewed to increase the knowledge about the disease. Methods A case of adult influenza-associated encephalitis admitted to Shanghai Public Health Clinical Center on Feb 2018 was analyzed. The clinical manifestations, diagnosis and treatment were described in detail. In addition, related literatures were reviewed to increase our knowledge about the disease for its early diagnosis and appropriate treatment. Results In the influenza prevailing season, central nervous system infection is possible. Influenza-associated encephalitis should be considered in the differential diagnosis. Cerebrospinal fluid, blood, pharynx swab and other specimens should be tested for its early diagnosis based on etiological(nucleic acid) and immunological evidence. Conclusion In patients with influenza and accompanying neurological symptoms, influenza-associated encephalitis may be possible. The susceptible populations should receive influenza vaccine annually to prevent the occurrence of influenza and its serious complications.

关 键 词：流感相关脑炎 中枢神经系统感染 核酸检测 

分 类 号：R511.7[医药卫生—内科学] R747.9[医药卫生—临床医学]