杨桃根水提取物化学成分及生物活性的研究  

Chemical constituents of the water extracts of Averrhoa carambola L. root and their biological activities

作　　者：廖彭莹[1] 周忠玉[2,3] 陈颖燃 陈慧萍 潘为高 杨小妹[1] 黄志祥 LIAO Peng-ying;ZHOU Zhong-yu;CHEN Ying-ran;CHEN Hui-ping;PAN Wei-gao;YANG Xiao-mei;HUANG Zhi-xiang(Guangxi University of Chinese Medicine,Nanning 530001,China;Key Laboratory of Plant Resources Conservation and Sustainable Utilization,South China Botanical Garden,Chinese Academy of Sciences;Guangdong Provincial Key Laboratory of Applied Botany,South China Botanical Garden,Chinese Academy of Sciences,Guangzhou 510650,China)

机构地区：[1]广西中医药大学,南宁530001 [2]中国科学院华南植物园中国科学院植物资源保护与可持续利用重点实验室 [3]广东省应用植物学重点实验室,广州510650

出　　处：《天然产物研究与开发》2019年第1期81-86,92,共7页Natural Product Research and Development

基　　金：广西自然科学基金(2015GXNSFBA139116);中国科学院植物资源保护与可持续利用重点实验室开放课题(PCU201503);2017年广西区级大学生创新创业训练计划(201710600070);广西中医药大学2018年广西一流学科建设项目重点课题(2018XK045)

摘　　要：为探究杨桃根中具备降血糖功能的活性成分,采用色谱分离方法从其水提取物中分离得到9个化合物,应用波谱技术对它们的化学结构进行了鉴定,分别命名为prismaconnatoside(1),tarennanosides A(2),(+)-catechin(3),fernandoside(4),7a-[(β-glucopyranosyl) oxy]-lyoniresinol(5),(+)-lyoniresinol 3α-O-β-D-glucopyranoside(6),(-)-lyon-iresinol 3α-O-β-D-glucopyranoside(7),(-)-5’-methoxy-isolariciresinol 3α-O-β-D-glucopyranoside(8)和正辛烷(9)。其中化合物1,2,4,5均为首次从杨桃中分离得到,化合物3为首次从杨桃根中分离得到。对部分单体化合物进行了体外α-葡萄糖苷酶和DPP-IV酶抑制活性测试,化合物1具有较强的α-葡萄糖苷酶抑制活性。To further investigate the antidiabetic constituents from the root of Averrhoa carambola L.,nine compounds were isolated from the water extracts by series column chromatographies and their structures were identified as prismaconnatoside(1),tarennanosides A(2),(+)-catechin(3),fernandoside(4),7a-[(β-glucopyranosyl)oxy]-lyoniresinol(5),(+)-lyoniresinol 3 α-O-β-D-glucopyranoside(6),(-)-lyoniresinol 3α-O-β-D-glucopyranoside(7),(-)-5’-methoxy-isolariciresinol 3α-O-β-D-glucopyranoside(8),and n-octane(9).Compounds 1,2,4,and 5 were isolated from Averrhoa carambola for the first time.Compound 3 was isolated from the root part of Averrhoa carambola for the first time.Some compounds were assayed for the α-glucosidase and DPP-IV inhibitory activities in vitro.Compound 1 showed α-glucosidase inhibitory activity.

关 键 词：杨桃根 化学成分 分离纯化 结构鉴定 α-葡萄糖苷酶抑制活性 

分 类 号：R284.2[医药卫生—中药学]