心脏老化以及预防机制研究的新进展  

New Advances in Mechanisms of Heart Aging and Prevention

作　　者：孙光[1] 齐国先[1] SUN Guang;QI Guoxian(Department of Geriatrics,The First Hospital of China Medical University,Shenyang 110001,Liaoning,China)

机构地区：[1]中国医科大学附属第一医院老年医学科,辽宁沈阳110001

出　　处：《心血管病学进展》2019年第1期80-83,共4页Advances in Cardiovascular Diseases

摘　　要：进行性心肌细胞肥大、炎症和心脏纤维化的逐渐发展是心脏衰老的标志。现概述心脏衰老中表现出的临床和细胞变化,以及维持体内平衡和延缓衰老的机制,这些机制包括自噬、泛素介导的蛋白质降解、细胞凋亡、线粒体稳态和心脏基质稳态并讨论心脏老化的干预措施,这些措施包括热量限制、雷帕霉素、白藜芦醇、生长分化因子-11和线粒体抗氧化剂等治疗剂。对干预措施的深入研究有望进一步改进治疗方式。The progressive development of cardiomyocyte hypertrophy,inflammation and cardiac fibrosis is a hallmark of cardiac aging.This review outlines the clinical and cellular changes demonstrated during cardiac aging,and the mechanisms that maintain homeostasis and delay aging.These mechanisms include autophagy,ubiquitin-mediated protein degradation,apoptosis,mitochondrial homeostasis,and cardiac matrix homeostasis.Finally,the intervention measures of heart aging are discussed.These include calorie restriction,rapamycin,resveratrol,growth differentiation factor 11 and mitochondrial antioxidants.Further research into interventions is expected to improve the treatment.

关 键 词：心脏衰老 衰老机制 老化干预 

分 类 号：R54[医药卫生—心血管疾病]