伊曲康唑联合阿莫罗芬乳膏治疗马拉色菌相关性皮肤病的疗效观察  

Therapeutic Effect of Itraconazole Combined with Amorolfine Cream on Malassezia-associated Skin Diseases

作　　者：汪静文 WANG Jing-wen(Department of Dermatology and Venereology,the Second Affiliated Hospital of Anhui Medical University,Hefei 230601,Anhui,China)

机构地区：[1]安徽医科大学第二附属医院皮肤病与性病科,安徽合肥230601

出　　处：《医学信息》2019年第1期157-159,共3页Journal of Medical Information

摘　　要：目的观察口服伊曲康唑胶囊联合外用阿莫罗芬乳膏治疗几种常见马拉色菌相关性皮肤病的临床疗效。方法选择2017年2月～9月我科门诊收治的经临床确诊的花斑糠疹、马拉色菌毛囊炎、脂溢性皮炎患者270例,随机分为治疗组136例和对照组134例。对照组患者口服伊曲康唑胶囊治疗,治疗组在此基础上对患者皮损处外用阿莫罗芬乳膏,比较两组临床疗效及不良反应情况。结果治疗组花斑糠疹、马拉色菌毛囊炎、脂溢性皮炎的治疗总有效率分别为92.86%、83.34%、83.34%,高于对照组的71.43%、52.94%、43.34%,差异有统计学意义(P<0.05);对照组5例患者口服伊曲康唑出现轻度胃肠道不适症状,治疗组2例患者皮疹部位轻度灼热,均不影响继续治疗,疗程结束停药后均消失。两组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论口服伊曲康唑胶囊联合阿莫罗芬乳膏外用治疗马拉色菌相关性疾病疗效确切,安全性高。Objective To observe the clinical efficacy of oral itraconazole capsule combined with topical amorolfine cream in the treatment of several common Malassezia-associated skin diseases.Methods A total of 270 patients with clinically diagnosed pityriasis,Malassezia folliculitis and seborrheic dermatitis were enrolled in our outpatient department from February to September 2017.They were randomly divided into 136 patients in the treatment group and 134 patients in the control group.The patients in the control group were treated with itraconazole capsules.The treatment group was treated with Amofufen cream on the skin lesions.The clinical efficacy and adverse reactions of the two groups were compared.Results The total effective rate of treatment of pityriasis,malassezia folliculitis and seborrheic dermatitis in the treatment group was 92.86%,83.34%and 83.34%,respectively,which was higher than that of the control group,71.43%,52.94%and 43.34%,the difference was statistically significant(P<0.05);5 patients in the control group had mild gastrointestinal discomfort symptoms with oral itraconazole,and 2 patients in the treatment group had mild rash in the rash area,which did not affect the continued treatment.After the drug disappeared.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The oral administration of itraconazole capsule combined with amorolfine cream for the treatment of Malassezia-related diseases is effective and safe.

关 键 词：伊曲康唑 阿莫罗芬 马拉色菌相关皮肤病 花斑糠疹 马拉色菌毛囊炎 脂溢性皮炎 

分 类 号：R756[医药卫生—皮肤病学与性病学]