TG、HDL-C、TC与糖尿病周围神经病变的相关性研究  

Correlation between TG,HDL-C,TC and diabetic peripheral neuropathy

作　　者：万芳[1] 曹玲玲[1] 孙斐[1] WAN Fang;CAO Lingling;SUN Fei(Department of Endocrinology,Jiujiang First People's Hospital in Jiangxi Province,Jiujiang 332000,China)

机构地区：[1]江西省九江市第一人民医院内分泌科,江西九江332000

出　　处：《中国现代医生》2018年第35期37-39,共3页China Modern Doctor

基　　金：江西省卫生计生委科技计划项目(20177080)

摘　　要：目的探讨甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)与糖尿病周围神经病变的相关性,为糖尿病周围神经病变诊断提供临床依据。方法回顾性分析2017年1月～2018年1月在我院内分泌科确诊为糖尿病周围神经病变患者48例作为DPN组,将同期我院收治的24例2型糖尿病患者作为T2DM组,分析两组甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(ApoB)等指标差异。通过Logistic回归方程分析上述指标与糖尿病周围神经病变的相关性。结果 DPN组TG、TC、LDL-C、ApoB水平均显著高于T2DM组,HDL-C显著低于T2DM组,差异均具有统计学意义(P<0.05);Logistic回归方程分析得出,TG、TC、HDL-C、LDL-C、ApoB均为DPN发病的危险因素(P<0.05)。结论糖尿病周围神经病变患者血脂水平高于单纯糖尿病患者,TG、TC、HDL-C、LDL-C、ApoB水平与DPN发病关系密切,是导致神经微血管病变的重要因素。Objective To explore the correlation between triglyceride(TG),high density lipoprotein cholesterol(HDL-C),total cholesterol(TC)and diabetic peripheral neuropathy,and to provide a clinical basis for the diagnosis of diabetic peripheral neuropathy.Methods A total of 48 patients with diabetic peripheral neuropathy diagnosed in our hospital from January 2017 to January 2018 were retrospectively analyzed and enrolled into the DPN group.Another 24 patients with type 2 diabetes admitted to our hospital during the same period were included in the T2DM group.The differences of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),and apolipoprotein B(ApoB)between the two groups were analyzed.And the correlation between these indicators and diabetic peripheral neuropathy were analyzed by logistic regression equation.Results The levels of TG,TC,LDL-C and ApoB in the DPN group were significantly higher than those in the T2DM group,and HDL-C was significantly lower in the DPN group than that in the T2DM group(P<0.05).Logistic regression equation analysis showed that TG,TC,and HDL-C,LDL-C,ApoB were risk factors for the onset of DPN(P<0.05).Conclusion The level of blood lipids in patients with diabetic peripheral neuropathy is higher than that in patients with diabetes alone.The levels of TG,TC and HDL-C,LDL-C,ApoB are closely related to the pathogenesis of DPN,which are important factors leading to neuromicrovascular disease.

关 键 词：甘油三酯(TG) 高密度脂蛋白胆固醇(HDL-C) 总胆固醇(TC) 2型糖尿病 周围神经病变 相关性 

分 类 号：R587.2[医药卫生—内分泌]