21例伴t(11;19)(q23;p13)白血病的临床和实验室特征  

Clinical and Laboratory Characteristics of the Patients with Leukemia t(11;19)(q23;p13)

作　　者：李丽 崔成华 徐建宁 艾晓非 王建祥[1] 李承文[1] LI Li;CUI Cheng-Hua;XU Jian-Ning(Center of Pathology,Institute of Hematology and Blood Disease Hospital,Chinese Academy of Medical Sciences and Graduate School of Peking Union Medical College,Tianjin 300020)

机构地区：[1]中国医学科学院,北京协和医学院血液学研究所,血液病医院,天津300020

出　　处：《临床输血与检验》2019年第1期87-91,38,共6页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的探讨伴t(11;19)(q23;p13)白血病临床实验室特点。方法回顾性分析21例初诊t(11;19)(q23;p13)患者的临床实验室资料,包括核型分析、荧光原位杂交、融合基因、细胞免疫表型等。结果 21例患者中,16例为t(11;19)(q23;p13.1),核型表现为(11q+,19p–),伴有融合基因MLL-ELL阳性。男7例,女9例。分型诊断:1例AML-M2,3例AML-M4,10例AML-M5,另2例为CMML;5例为t(11;19)(q23;p13.3),核型表现为(11q–,19p+),伴有融合基因MLL-ENL阳性。1例男性,4例女性。分型诊断:3例proB-ALL,1例preB-ALL,1例T-ALL。结论 t(11;19)(q23;p13)为少见的非随机染色体易位,t(11;19)(q23;p13.1)主要在成人急性髓系白血病(AML)出现,且与单核系相关,而t(11;19)(q23;p13.3)主要在婴幼儿及儿童急性淋巴细胞白血病(ALL)中出现。Objective To analyze the clinical and laboratory characteristics of Leukemia with t(1 1;1 9)(q23;p13).Methods Twenty-one patients with(11;19)(q23;p13)were reviewed including the data of conventional cytogenetic analysis,fluorescence in situ hybridization(FISH),fusion genes,and immunophenotype.Results Sixteen of 2 1 patients carry t(1 1;1 9)(q2 3;p1 3.1),showing 1 1q+and 1 9p– derivatives and positive MLL/ELL fusion genes.Seven males and nine females were definitively diagnosed,among them,one shows M2;3,M4;and 10,M5.The other 2 cases were CMML.Five of 21 patients were t(11;19)(q23;p13.3),exhibiting 11q-and 19p+derivatives and positive MLL/ENL fusion genes.One male and four females were identified,3 cases were classified as proB-ALL,1 as preB-ALL,and 1 as T-ALL.Conclusions The t(1 1;1 9)(q2 3;p1 3)abnormality is one of the rare and non-random chromosomal translocations.The t(11;19)(q23;p13.1)are mostly seen in the patients with acute myeloid leukemia(AML)in adults.Comparatively,the t(11;19)(q23;p13.3)frequently occurs in the infants and children with malignancies of lymphoid lineage.

关 键 词：t(11 19) 白血病 MLL/ELL MLL/ENL 

分 类 号：R446[医药卫生—诊断学] R733.7[医药卫生—临床医学]