成纤维细胞生长因子-1治疗糖尿病及相关疾病的研究进展  

Research progress of fibroblast growth factor 1 in the treatment of diabetes and related diseases

作　　者：金辉[1] 周子晔[1] 梁晶[1] 王陈翔[1] 宋林涛 赵龙伟 郭凯文 JIN Hui;ZHOU Ziye;LIANG Jing;WANG Chenxiang;SONG Lintao;ZHAO Longwei;GUO Kaiwen(Department of Pharmacy of the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang,China;School of Pharmacy of Wenzhou Medical University,Wenzhou 325000,Zhejiang,China)

机构地区：[1]温州医科大学附属第一医院药学部 [2]温州医科大学药学院

出　　处：《中国临床药理学与治疗学》2019年第1期111-115,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：温州市公益性科技计划项目(Y20160162)

摘　　要：酸性成纤维细胞生长因子(又称FGF-1)作为较早发现的成纤维细胞生长因子家族的重要成员,其刺激血管生长、加速创伤愈合和促进神经损伤修复等作用已被广泛认可,近年来它在内分泌系统中潜在的生物学功能的研究也成为热点。本文就FGF-1的结构功能、受体信号转导通路及对糖尿病的治疗作一综述。Fibroblast growth factor(FGF-1),as found earlier as an important member of fibroblast growth factor family,has been widely recognized as can stimulate the growth of blood vessels,accelerate wound healing and promote nerve injury.In recent years,the potential biological function of FGF-1 in endocrine system has become a research focus.This article reviews the structure,function,receptor signaling pathway of FGF-1 and its role in the treatment of diabetes and related diseases.

关 键 词：成纤维细胞生长因子-1 糖尿病 

分 类 号：R587[医药卫生—内分泌]