高血压伴左室肥厚患者外周血T细胞亚群与血管紧张素Ⅱ水平的相关性  

Correlation between T cell subset in peripheral blood and angiotensin Ⅱ in patients with hypertension complicated by left ventricular hypertrophy

作　　者：古忆[1] 高翔 张小兵[1] 刘志明 夏思良[1] Gu Yi;Gao Xiang;Zhang Xiaobing;Liu Zhiming;Xia Siliang(Department of Cardiology,Jiangbei People's Hospital,Nanjing 210048,China)

机构地区：[1]南京江北人民医院心内科,南京210048

出　　处：《中国循证心血管医学杂志》2018年第12期1503-1505,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：江苏省南京市医学科技发展计划项目(YKK16268)

摘　　要：目的观察高血压伴左室肥厚患者外周血T细胞亚群与血管紧张素Ⅱ(AngⅡ)水平变化及其相关性。方法连续入选南京江北人民医院心内科收治的160例高血压患者,根据是否合并左室肥厚将入选患者分为两组,即观察组(高血压伴左室肥厚)和单纯高血压组(高血压无左室肥厚),同时选择40例健康体检者为对照组。分析三组受试者外周血Th1、Th2、Th17细胞比例及AngⅡ、血管紧张素Ⅱ1型受体(AT1R)水平变化,并研究其相关性。结果观察组患者外周血Th1、Th17细胞比例及Th1/Th2值均显著大于单纯高血压组和对照组(P<0.05),而三组患者外周血Th2细胞比例比较,差异无统计学意义(P>0.05)。观察组患者AngⅡ及AT1R水平均明显高于单纯高血压组和对照组,差异具有统计学意义(P<0.05)。高血压伴左室肥厚患者外周血AngⅡ、AT1R水平与Th1、Th17细胞比例及Th1/Th2值均呈显著正相关(P<0.05)。结论高血压伴左室肥厚患者Th1、Th17细胞比例及AngⅡ、AT1R水平均明显升高,这可能与高血压患者左室肥厚的发生和发展密切相关。Objective To observe the level changes of T cell subset in peripheral blood and angiotensinⅡ(AngⅡ)and correlation between them in patients with hypertension complicated by left ventricular hypertrophy(LVH).Methods Hypertensive patients(n=160)were continuously chosen and then divided,according to whether or not they were complicated by LVH,observation group(hypertension+LVH)and hypertension group(without LVH),and meanwhile healthy cases(n=40)were chosen into control group.The proportions of Th1,Th2 and Th17 in peripheral blood,and level changes of AngII and angiotensin II type 1 receptor(AT1R)were analyzed and correlation among them were analyzed in 3 groups.Results The value of proportions of Th1 and Th17 and ratio of Th1 to Th2 were significantly higher in observation group than those in hypertension group and control group(P<0.05).The comparison in proportion of Th2 showed that difference had no statistical significance in 3 groups(P>0.05).The levels of AngⅡand AT1R were significantly higher in observation group than those in hypertension group and control group(P<0.05).The levels of AngII and AT1R were positively correlated to proportions of Th1 and Th17 and ratio of Th1 to Th2(P<0.05)in patients with hypertension complicated by LVH.Conclusion The proportions of Th1 and Th17 in peripheral blood and levels of AngⅡand AT1R increase significantly in patients with hypertension complicated by LVH,which may be closely related to LVH occurrence and development in hypertensive patients.

关 键 词：左室肥厚 高血压 T细胞亚群 血管紧张素Ⅱ 

分 类 号：R544.1[医药卫生—心血管疾病]