血清CysC、hs-CRP、Lp(a)在急性冠脉综合征患者中的表达及临床意义  

Expression and clinical significance of serum CysC, hs-CRP and Lp(a) in patients with acute coronary syndrome

作　　者：郭庆[1] 成鑫 严洁婷 叶鸿[1] GUO Qing;CHENG Xin;YAN Jieting;YE Hong(Department of Geratology,Huangshi Central Hospital of Edong Healthcare Group Affiliated Hospital of Hubei Polytechnic University,Hubei Province,Huangshi 435000,China)

机构地区：[1]鄂东医疗集团黄石市中心医院湖北理工学院附属医院老年病科,湖北黄石435000

出　　处：《中国医药导报》2019年第2期54-58,共5页China Medical Herald

基　　金：湖北省黄石市科学技术局[黄科技发农(2014)3号]

摘　　要：目的探讨血清胱抑素C(CysC)、高敏C反应蛋白(hs-CRP)、脂蛋白a[Lp(a)]在急性冠脉综合征患者中的表达及临床意义。方法选取2016年10月~2018年5月鄂东医疗集团黄石市中心医院106例急性冠脉综合征患者设为研究组,另选取同期健康体检者106名设为对照组。入院后第2天晨起时抽取所有受检者空腹静脉血4 mL,以免疫透射比浊法测定血清Lp(a)水平,以酶联免疫吸附法测定血清CysC、hs-CRP水平。统计研究组与对照组、不同病理类型急性冠脉综合征患者、不同病变支数急性冠脉综合征患者、不同病情程度急性冠脉综合征患者血清CysC、hs-CRP、Lp(a)水平,分析血清CysC、hs-CRP、Lp(a)水平与急性冠脉综合征病情程度相关性,并比较血清CysC、hs-CRP、Lp(a)单独及联合诊断急性冠脉综合征效能。结果研究组血清CysC、hs-CRP、Lp(a)水平高于对照组,差异有高度统计学意义(P <0.01)。不同病理类型急性冠脉综合征患者血清CysC、hs-CRP、Lp(a)水平间差异有高度统计学意义(P <0.01),且不稳定型心绞痛患者血清CysC、hs-CRP、Lp(a)水平高于稳定型心绞痛,急性心肌梗死患者血清CysC、hs-CRP、Lp(a)水平高于不稳定型心绞痛,差异有高度统计学意义(P <0.01)。不同病变支数急性冠脉综合征患者血清CysC、hs-CRP、Lp(a)水平间差异有高度统计学意义(P <0.01),且双支病变患者血清CysC、hs-CRP、Lp(a)水平高于单支病变,三支病变患者血清CysC、hs-CRP、Lp(a)水平高于双支病变,差异有统计学意义(P <0.05)。不同病情程度急性冠脉综合征患者血清CysC、hs-CRP、Lp(a)水平间差异有高度统计学意义(P <0.01),且中度患者血清CysC、hs-CRP、Lp(a)水平高于轻度,重度患者血清CysC、hs-CRP、Lp(a)水平高于中度,差异有统计学意义(P <0.05)。Pearson检验结果显示:血清CysC、hs-CRP、Lp(a)水平均与急性冠脉综合征病情程度呈明显正相关(r=0.663、0.691、0.652,P <0.05)。联合�Objective To explore the expression and clinical significance of serum Cystatin C(CysC),high sensitivity C reactive protein(hs-CRP),lipoprotein a[Lp(a)]in patients with acute coronary syndrome.Methods From October 2016 to May 2018,in Huangshi Central Hospital,Edong Healthcare Group,106 patients with acute coronary syndrome were selected as the study group,at the same time,106 healthy persons were selected as the control group.At the second morning,4 mL fasting venous blood was taken from all subjects.Serum Lp(a)levels were measured by immunoturbidimetry and serum CysC and hs-CRP levels were measured by enzyme-linked immunosorbent assay.The levels of serum CysC,hs-CRP and Lp(a)in the study group and control group,patients with different pathological types of acute coronary syndrome,patients with different pathological changes of acute coronary syndrome,and patients with different severity of acute coronary syndromes were observed.The correlation between serum CysC,hs-CRP,Lp(a)and the severity of acute coronary syndrome was analyzed.And the efficacy of serum CysC,hs-CRP and Lp(a)alone and combined in the diagnosis of acute coronary syndrome were compared.Results The levels of serum CysC,hs-CRP and Lp(a)in the study group were higher than those in the control group,the differences were statistically significant(P﹤0.01).There were statistically significant differences in serum levels of CysC,hs-CRP and Lp(a)in patients with different pathological types of acute coronary syndrome(P﹤0.01).The serum levels of CysC,hs-CRP and Lp(a)in patients with unstable angina pectoris were higher than patients with stable angina,the levels of serum CysC,hs-CRP and Lp(a)in patients with acute myocardial infarction were higher than patients with unstable angina pectoris,the differences were statistically significant(P﹤0.01).There were statistically significant differences in serum levels of CysC,hs-CRP and Lp(a)in patients with different coronary artery lesions(P﹤0.05).The levels of serum CysC,hs-CRP and Lp(a)in patients with d

关 键 词：CYSC HS-CRP Lp(a) 病情程度 急性冠脉综合征 病理类型 

分 类 号：R541.4[医药卫生—心血管疾病]