CETP基因I405V、1696G/A多态与辛伐他汀疗效的相关性  

Association of CETP gene I405V and 1696G/A polymorphisms with Simvastatin efficacy

作　　者：李俊涛[1] 郭志斌[2] 陈志超[1] 保泽庆[1] 王敏[1] 郑克勤 LI Juntao;GUO Zhibin;CHEN Zhichao;BAO Zeqing;WANG Min;ZHENG Keqin(Department of Basic Medicine,Zhaoqing Medical College,Guangdong Province,Zhaoqing 526020,China;Medical Laboratory,Affiliated Hospital of Nantong University,Jiangsu Province,Nantong 226001,China;Department of Medical Genetics,Guangdong Medical University,Guangdong Province,Zhanjiang 524023,China)

机构地区：[1]肇庆医学高等专科学校基础医学部,广东肇庆526020 [2]南通大学附属医院医学检验科,江苏南通226001 [3]广东医科大学医学遗传学研究室,广东湛江524023

出　　处：《中国医药导报》2019年第2期127-130,共4页China Medical Herald

摘　　要：目的探讨胆固醇酯转运蛋白(CETP)基因I405V多态、1696G/A多态与辛伐他汀调血脂效果的相关性。方法选取2008年2月～2010年6月于广东医科大学附属医院治疗的血脂异常患者233例,采用聚合酶链反应-限制性片段长度多态(PCR-RFLP)方法检测I405V和1696G/A多态的基因型频率分布情况,并比较各基因型之间的各项血脂水平在辛伐他汀调脂治疗前后的变化。结果 I405V多态Ⅱ、Ⅳ及ⅤⅤ基因型分别为63例、101例和69例,1696G/A多态GG、GA及AA基因型分别为167例、45例和21例。辛伐他汀治疗后,Ⅱ型患者三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及极低密度脂蛋白胆固醇(VLDL-C)水平的下降幅度最为明显(P <0.05或P <0.01);1696G/A多态各基因型患者各项血脂水平变化量比较差异无统计学意义(P> 0.05)。结论辛伐他汀调血脂效果与CETP基因I405V多态相关。Objective To explore the association between the lipid-regulating effect of Simvastatin with I405V and 1696G/A polymorphisms in cholesteryl ester transfer protein(CETP)gene.Methods Two hundred and thirty-three cases of patients with dyslipidemia treated in Affiliated Hospital of Guangdong Medical University from February 2008 to June 2010 were selected.Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)technique was used to detect the genotype frequency distribution of I405V and 1696G/A polymorphisms,and the change of each blood-fat index among different genotypes was compared before and after Simvastatin treatment.Results The distribution of II,IV and VV genotype of I405V polymorphism were 63 cases,101 cases and 69 cases respectively.The GG,GA and AA genotype distribution of 1696G/A polymorphism were 167 cases,45 cases and 21 cases respectively.After Simvastatin treatment,the decline of triacylglycerol(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and very low density lipoprotein cholesterol(VLDL-C)in II genotype patients was the most obvious(P﹤0.05 or P﹤0.01).There was no statistically significant difference in the change of blood lipid levels among all kinds of 1696G/A genotype patients(P﹥0.05).Conclusion The effect of Simvastatin on blood lipid is related to the I405V polymorphism of CETP gene.

关 键 词：胆固醇酯转运蛋白 血脂异常 辛伐他汀 三酰甘油 低密度脂蛋白 

分 类 号：R589.2[医药卫生—内分泌]