血清INHB、IGF-1、VEGF、E2在多囊卵巢综合征患者中的表达及临床意义  

Expression and significance of serum INHB,IGF-1,VEGF and E2 in patients with polycystic ovary syndrome

作　　者：沈澍[1] 周晓燕[1] 胡恒贵[1] 孟靠 SHEN Shu;ZHOU Xiaoyan;HU Henggui;MENG Kao(Department of Reproductive Medicine,General Hospital of Wanbei Coal Group,Suzhou,Anhui 234000,China)

机构地区：[1]宿州市皖北煤电集团总医院生殖科,安徽宿州234000

出　　处：《国际检验医学杂志》2019年第2期181-183,187,共4页International Journal of Laboratory Medicine

基　　金：安徽省自然科学基金资助项目(1508085SMD218)

摘　　要：目的探讨血清抑制素B(INHB)、类胰岛素样生长因子1(IGF-1)、血管内皮生长因子(VEGF)及雌二醇(E2)在多囊卵巢综合征(PCOS)患者中的表达及临床意义。方法选择2015年4月至2016年5月该院接诊的45例PCOS患者作为观察组,另选择同期因男方因素不孕而进行体检的健康女性45例作为对照组。分析血清INHB、IGF-1、VEGF、E2在PCOS中的表达意义及诊断价值。结果观察组患者血清INHB、IGF-1、VEGF、E2水平均高于对照组,差异均有统计学意义(P<0.05);INHB、IGF-1、VEGF、E2诊断PCOS的受试者工作特征曲线(ROC曲线)曲线下面积(AUC)分别为0.935、0.988、0.992、0.759,诊断PCOS的灵敏度分别为80.93%、81.18%、79.12%、79.07%,特异度分别为73.05%、75.17%、77.49%、78.59%。结论血清INHB、IGF-1、VEGF、E2在PCOS患者中呈高表达,可作为诊断PCOS的重要指标。ObjectiveTo study the expression and significance of serum inhibin B(INHB),insulin-like growth factor-1(IGF-1),vascular endothelial growth factor(VEGF)and estradiol(E2)in patients with polycystic ovary syndrome(PCOS).MethodsA total of 45 patients with PCOS in the hospital from April 2015 to May 2016,were selected as observation group.In addition,45 healthy women who underwent physical examination due to male infertility were selected as control group.The significance and diagnostic value of serum INHB,IGF-1,VEGF and E2 in PCOS were analyzed.ResultsThe levels of serum INHB,IGF-1,VEGF and E2 in observation group were significantly higher than those of control group(P<0.05).The receiver operating characteristic curve(ROC curve)analysis showed that the AUC of INHB,IGF-1,VEGF and E2 were 0.935,0.988,0.992 and 0.759,respectively.The sensitivity of PCOS were 80.93%,81.18%,79.12%and 79.07%,while the specificity of PCOS were 73.05%,75.17%,77.49%and 78.59%,respectively.ConclusionSerum INHB,IGF-1,VEGF and E2 are highly expressed in patients with PCOS,which can be used as an important indicators in the diagnosis of PCOS.

关 键 词：多囊卵巢综合征 血清抑制素B 类胰岛素样生长因子1 血管内皮生长因子 雌二醇 

分 类 号：R446.11[医药卫生—诊断学] R711.75[医药卫生—临床医学]