开管毛细管电色谱在手性药物拆分方面的研究进展  

Research Progress on Enantiomeric Separations of Drug by Open Tubular Capillary Electrochromatography

作　　者：文乐娟 龙琴 阴香萍 臧文婷 董旭阳 刘春叶[1] WEN Le-juan;LONG Qin;YIN Xiang-ping;ZANG Wen-ting;DONG Xu-yang;LIU Chun-ye(School of Pharmacry,Xi'an Medical University,Shaanxi Xi'an 710021,China)

机构地区：[1]西安医学院药学院,陕西西安710021

出　　处：《广州化工》2019年第2期16-19,共4页GuangZhou Chemical Industry

基　　金：国家自然科学基金(No:81202492);国家级大学生创新创业项目(No:201711840015);陕西省大创项目(No:2317);校级大创项目(No:2017DC-10)

摘　　要：手性药物的有效拆分以及优化拆分条件对医药行业有着重大意义。本文就开管毛细管电色谱技术及其对手性药物的拆分研究进行展开简要概述综述,分别对糖类衍生物、金属-有机骨架化合物、大环抗生素、蛋白质等物质作为开管毛细管电色谱柱手性选择剂的制备和应用,以及各自的优缺点进行了简要综述,并对其做出展望,为开管毛细管电色谱技术对手性药物的拆分研究提供理论参考。The chiral separations and identification of chiral drugs are gaining importance in pharmaceuticals and other fields.The research progress on chiral separations of drugs by using open tubular capillary electrochromatography(OTCE)was discussed.Chiral selective materials used in OTCE,such as derivatives of carbohydrate,metal organic frameworks,macrocyclic antibiotics and protein,were reviewed,their applications,advantages and disadvantages were also discussed.The trends and future challenges of the method were summarized,which would provide theory references for chiral drug separations in OTCE.

关 键 词：手性药物 毛细管电色谱 开管柱 

分 类 号：O657.8[理学—分析化学]