细胞自噬与疾病的研究进展  

Research Progress of the Autophagy and Disease

作　　者：焦寒伟 王红均 赵宇[1] 伍莉[1] 帅学宏 陈吉轩 甘玲[1] 罗献梅 黄庆洲[1] JIAO Han-wei;WANG Hong-jun;ZHAO Yu(College of Animal Sciences,Southwestern University,Chongqing Veterinary Scientific Engineering Research Center,Chongqing 402460)

机构地区：[1]西南大学动物科学学院,重庆市兽医科学工程研究中心,重庆荣昌402460

出　　处：《安徽农业科学》2019年第2期10-14,共5页Journal of Anhui Agricultural Sciences

基　　金：国家自然科学基金项目(31802215);重庆市自然科学基金项目(cstc2018jcyjA0807);西南大学科研基金资助项目(20700505)

摘　　要：细胞自噬(Autophagy)是细胞将受损的细胞器、废弃细胞质和变性或衰老的蛋白质转运至溶酶体(Lysosome),并进行酶解的一个生物学过程。在真核生物中,细胞自噬是一个高度保守的过程,而自噬是细胞的一种自我保护机制,维持了细胞内稳态。自噬在细胞程序性死亡(Programmed cell death,PCD)、心血管疾病、肝脏疾病、神经性疾病、癌症与肿瘤以及自身免疫性疾病等多种疾病过程扮演了重要的角色。该文综述了细胞自噬与多种疾病的研究进展,提示了细胞自噬在免疫相关性疾病过程中发挥着重要的调控作用,从而阐明细胞自噬可能作为疾病治疗的新靶点和突破口,为治疗免疫相关性疾病做铺垫。Autophagy is a biological process in which cells transport the damaged organelles,waste cytoplasm and denatured or senescent proteins to lysosome,and then undergo enzymatic hydrolysis.Autophagy is a highly conserved process in eukaryotes,and autophagy is a cell self-protective mechanism which maintains the intracellular homeostasis.Autophagy plays an important role in the programmed cell death(PCD),cancer,cardiovascular disease,liver disease,neurodegenic diseases,cancer and tumor,autoimmune diseases and other disases.It was suggested that the autophagy played an important role in the process of immuno related diseases,thus clarifying that cell autophagy may be a new target and breakthrough in the treatment of immune related disease,and pave the way for the treatment of immune related diseases.

关 键 词：细胞自噬 溶酶体 真核生物 疾病 

分 类 号：Q291[生物学—细胞生物学]