布地奈德与异丙托溴铵溶液联合干扰素α1b治疗小儿麻疹合并肺炎的效果评价  

Evaluation of the efficacy of budesonide combined with ipratropium bromide solution combined with interferon α1b in the treatment of pediatric measles complicated with pneumonia

作　　者：王周菊[1] 林菁[1] WANG Zhou-ju;LIN Jing(Department of Pediatrics,Guangzhou Eighth People’s Hospital,Guangzhou 510060,China)

机构地区：[1]广州市第八人民医院儿科,510060

出　　处：《中国现代药物应用》2019年第2期7-8,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨布地奈德与吸入用异丙托溴铵溶液联合干扰素α1b雾化治疗小儿麻疹合并肺炎的临床效果。方法 76例小儿麻疹合并肺炎患儿,随机分为对照组和观察组,各38例。对照组采用常规方法治疗,观察组在常规治疗基础上采用布地奈德与吸入用异丙托溴铵溶液联合干扰素α1b雾化治疗,比较两组患儿的临床疗效、症状或体征消退时间、住院时间、免疫因子水平。结果观察组总有效率为97.37%,高于对照组的78.95%,差异有统计学意义(P<0.05)。观察组咳嗽消退时间、腹泻消退时间、退热时间、皮疹消退时间、血液生化指标恢复时间、肺部啰音消失时间、X线胸片影消失时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,观察组CD3+(68.02±7.61)%、CD4+(40.19±5.17)%、CD4+/CD8+(1.51±0.38)均明显高于对照组的(64.53±7.13)%、(36.28±4.16)%、(1.14±0.36), CD8+(27.10±4.46)%明显低于对照组的(30.75±4.21)%,差异有统计学意义(P<0.05)。结论布地奈德与吸入用异丙托溴铵溶液联合干扰素α1b雾化治疗小儿麻疹合并肺炎临床效果显著,能够增强抗病毒及抗炎效果,调节机体免疫功能,促进症状的早期消退,具有积极的临床意义。Objective To discuss the clinical effect of budesonide combined with ipratropium bromide solution combined with interferonα1 b in the treatment of pediatric measles complicated with pneumonia.Methods A total of 76 children with measles complicated with pneumonia were randomly divided into control group and observation group,with 38 cases in each group.The control group received conventional therapy for treatment,and the observation group received budesonide combined with ipratropium bromide solution for inhalation combined with interferonα1 b on the basis of conventional therapy.Comparison were made on clinical efficacy,symptom or signs subsidence time,hospitalization time,immune factor level between the two groups.Results The observation group had higher total effective rate as 97.37%than 78.95%in the control group,and the difference was statistically significant(P<0.05).The observation group had shorter cough subsidence time,diarrhea subsidence time,antipyretic time,rash subsidence time,blood biochemical index recovery time,lung rale subsidence time,chest X-ray shadow subsidence time and hospitalization time than the control group,and their difference was statistically significant(P<0.05).After treatment,the observation group had obviously higher CD3^+as(68.02±7.61)%,CD4^+as(40.19±5.17)%and CD4^+/CD8^+as(1.51±0.38)than(64.53±7.13)%,(36.28±4.16)%,(1.14±0.36)in the control group,and obviously lower CD8^+as(27.10±4.46)%than(30.75±4.21)%in the control group.Their difference was statistically significant(P<0.05).Conclusion Budesonide and ipratropium bromide solution for inhalation combined with interferonα1 b aerosol therapy shows remarkable clinical effect in treating pediatric measles complicated with pneumonia,and it can enhance the antivirus and anti-inflammatory effect,regulate the immune function of the body,promote the early disappearance of symptoms.This method contains positive clinical significance.

关 键 词：小儿麻疹合并肺炎 布地奈德 吸入用异丙托溴铵溶液 干扰素Α1B 雾化治疗 

分 类 号：R725.6[医药卫生—儿科] R725.1[医药卫生—临床医学]