表观健康人群中白细胞减少的临床分析  

Clinical analysis of apparently healthy subjects with leukopenia

作　　者：郝青 甄长青[2] HAO Qing;ZHEN Changqing(Department of Clinical Laboratory,Provincial Hospital Affiliated To Shandong University,Jinan,Shandong 250021,China;Department of Hematology,Provincial Hospital Affiliated To Shandong University,Jinan,Shandong 250021,China)

机构地区：[1]山东大学附属省立医院临床医学检验部,山东济南250021 [2]山东大学附属省立医院血液科,山东济南250021

出　　处：《国际检验医学杂志》2019年第3期257-259,265,共4页International Journal of Laboratory Medicine

基　　金：山东省医药卫生科技发展计划项目(2017WS100)

摘　　要：目的探讨表观健康人群中白细胞减少症的发生率及其与年龄、性别的相关性。方法选取2018年1-7月该院健康体检者40 031例为研究对象,其中男23 393例,女16 638例,对其进行血常规检测,分析白细胞减少者中年龄、性别、中性粒细胞(粒细胞)减少与缺乏的情况。结果表观健康人群中白细胞减少症的患病率为1.22%(490/40 031),男性为0.37%(151/40 031),女性为0.85%(339/40 031),女性发病率更高,男女之间差异有统计学意义(P<0.05);年龄:男性平均年龄较大,≥60岁与<60岁的人群发病率相比差异无统计学意义(P>0.05);白细胞减少人群中男女性别间淋巴细胞及单核细胞计数差异无统计学意义(P>0.05),而白细胞、中性粒细胞计数差异有统计学意义(P<0.05)。白细胞减少者中中性粒细胞减少者有206例,占42.04%(206/490),而白细胞减少者中合并血小板减少有21例,占4.29%(21/490),合并血红蛋白减少者有71例,占14.49%(71/490)。结论白细胞减少症在健康人群中的发病率为1.22%,女性发病率更高,≥60岁与<60岁的人群发病率差异无统计学意义。在白细胞减少人群中,女性比男性白细胞减少的严重程度要高,伴发中性粒细胞减少的情况也更严重。Objective To investigate the incidence of leukopenia in superficial healthy population and its correlation with age and sex.Methods A total of 40 031 healthy subjects,including 23 393 males and 16 638 females,were selected from January to July,2018.Their blood routine tests were performed to analyze the age,sex,neutropenia of leukopenia patients.Results The prevalence of leukopenia was 1.22%(490/40 031),0.37%(151/40 031)in males,0.85%(339/40 031)in females.The incidence in females was higher,with statistical significance(P<0.05).Age:the average age of males was higher.There was no difference between the incidence of leukopenia in the population aged less than 60 years and over 60 years.There was no significant difference in lymphocyte and monocyte counts between men and women with leukopenia(P>0.05),but there was significant difference in WBC and NEU counts(P<0.05).Neutropenia was found in 206 leukopenia patients,accounting for 42.04%(206/490),and thrombocytopenia was found in 21 patients,accounting for 4.29%(21/490),and anemia was found in 71 patients,accounting for 14.49%(71/490).Conclusion The incidence of leukopenia is 1.22%in the apparently healthy population.The incidence of leukopenia in females is higher than that in males.Leukopenia is more severe in women than in men,neutropenia is more severe too.

关 键 词：表观健康人群 白细胞减少 中性粒细胞减少 性别 年龄 

分 类 号：R446.1[医药卫生—诊断学]