一个镍(Ⅱ)配合物的合成、晶体结构及其与鲱鱼精DNA/BSA作用的光谱学研究  

Synthesis,Crystal Structure and DNA/BSA Interaction of a Ni(Ⅱ) Coordination Compound

作　　者：彭程佳 王克华 陆为学 管纯倩 胡雅静 马双 朱明昌[2] 高恩君[2] PENG Chen-jia;WANG Ke-hua;LU Wei-xue;GUAN Chun-qian;HU Ya-jing;MA Shuang;ZHU Ming-chang;GAO En-jun(School of Chemistry and Life Science,Anshan Normal University,Anshan 114007,China;Laboratory of Coordination Chemistry,Shenyang University of Chemical Technology,Shenyang 110142,China)

机构地区：[1]鞍山师范学院化学与生命科学学院,辽宁鞍山114007 [2]沈阳化工大学配位化学研究室,辽宁沈阳110142

出　　处：《光谱学与光谱分析》2019年第2期559-564,共6页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金项目(21671138);鞍山市科技计划项目(2014MS15);辽宁省大学生创新创业项目(201610169004)资助

摘　　要：合成了配合物[Ni(2,2′-biby)(H2O)4]·(Htba)2·5H2O单晶,分子式中2,2′-biby为2,2′-联吡啶,H2tba为2-硫代巴比妥酸。通过红外光谱、元素分析和单晶X-射线衍射表征其结构,单晶X-射线衍射结果表明,该配合物单晶属于正交晶系,Pbca空间群,晶胞参数为a=13.662(2),b=19.470(4),c=21.590(4)。应用紫外光谱和荧光光谱研究了其与鲱鱼精DNA/牛血清白蛋白(BSA)的相互作用,研究结果表明,标题化合物与DNA为静电结合,对牛血清白蛋白发生静态猝灭作用。A Ni(Ⅱ)coordination complex[Ni(2,2′-biby)(H2O)4]·(tba)2·5H2O(2,2′-biby=2,2′-dipyridine,H2tba=2-thiobarbituric acid)has been synthesized and structurally characterized by IR,element analysis and single crystal X-ray diffractometry.The results of single crystal X-ray diffractometry displayed that the title compound belongs to orthorhombic with space group of Pbca,and its cell parameters are a=13.662(2)A,b=19.470(4)A,c=21.590(4)A.The binding of title compound with Herring sperm DNA/BSA has been investigated by absorption and fluorescence spectra,and the results displayed that the title compound binds with DNA in electrostatic interaction mode,and quenches the intrinsic fluorescence of BSA by a static quenching mechanism.

关 键 词：配合物 DNA作用 BSA作用 晶体结构 

分 类 号：O611.3[理学—无机化学]