血清降钙素原和超敏C-反应蛋白在小儿急性上呼吸道感染性疾病中的诊断价值  

Diagnostic value of serum procalcitonin and hypersensitive C-reactive protein in children with acute upper respiratory tract infectious diseases

作　　者：高海锋[1] 乔芬[2] 赵秋剑[1] 张红艳[3] GAO Haifeng;QIAO Fen;ZHAO Qiujian;ZHANG Hongyan(Department of Clinical Laboratory,Baoji Municipal Central Hospital,Baoji,Shaanxi 721008,China;Department of Pediatrics,Baoji Municipal Central Hospital,Baoji,Shaanxi 721008, China;Department of Respiration,Baoji Municipal Hospital of Traditional Chinese Medicine,Baoji,Shaanxi 721001,China)

机构地区：[1]陕西省宝鸡市中心医院检验科,721008 [2]陕西省宝鸡市中心医院儿科,721008 [3]陕西省宝鸡市中医医院呼吸内科,721001

出　　处：《检验医学与临床》2019年第3期379-381,384,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨降钙素原(PCT)和超敏C-反应蛋白(hs-CRP)检测在小儿急性呼吸道感染性疾病中的诊断价值,为急诊患儿早期治疗提供依据。方法选择2017年1月至2018年1月宝鸡市中心医院和宝鸡市中医医院儿科急性上呼吸道感染患儿522例,其中细菌感染患儿(细菌感染组)176例、病毒感染患儿(病毒感染组)268例、支原体感染患儿(支原体感染组)78例。同时,选择50例健康儿童作为对照组,分别检测PCT和hs-CRP的水平。对检测结果进行统计学分析。结果细菌感染组PCT和hs-CRP水平明显高于其他3组(P<0.05),支原体感染组PCT和hs-CRP水平明显高于病毒感染组和对照组(P<0.05),病毒感染组hs-CRP水平明显高于对照组(P<0.05),但病毒感染组PCT水平与对照组比较差异无统计学意义(P>0.05)。细菌感染组PCT和hs-CRP阳性率明显高于其他3组,差异有统计学意义(P<0.05);支原体感染组PCT和hsCRP阳性率明显高于病毒感染组和对照组,差异有统计学意义(P<0.05);病毒感染组PCT阳性率高于对照组,差异有统计学意义(P<0.05),但hs-CRP阳性率差异无统计学意义(P>0.05)。血清PCT、hs-CRP单独及联合检测对细菌性上呼吸道感染的ROC曲线下面积分别为0.850、0.797、0.913,灵敏度分别为76.8%、85.6%、92.3%,特异度分别为88.7%、72.3%、83.4%,PCT、hs-CRP单独诊断细菌性上呼吸道感染的截断值分别为0.62ng/mL、8.23mg/L。结论血清PCT和hs-CRP水平检测可用于小儿上呼吸道感染性疾病的诊断及鉴别诊断,可为早期合理用药提供依据。Objective To investigate the diagnostic value of serum procalcitonin(PCT)and hypersensitive C-reactive protein(hs-CRP)in children with acute upper respiratory tract infectious diseases to provide the basis for early treatment of emergency cildren patients.Methods A total of 522 children cases of acute upper respiratory tract infection in the Baoji Municipal Central Hospital and Baoji Municipal Hospital of Traditional Chinese Medicine from Jan.2017 to Jan.2018 were selected,including 176 cases of bacteria infection(bacterial infection group),268 cases of viral infection(viral infection group)and 78 cases of mycoplasma infection(mycoplasma infection group).Meanwhile,50 healthy children were selected as the control group.The serum PCT and hs-CRP levels were detected respectively.Then the detection results were analyzed statistically.Results The serum PCT and hs-CRP levels of the bacterial infection group were significantly higher than those of other 3 groups(P<0.05).The serum PCT and hs-CRP levels of the mycoplasma infection group were significantly higher than those of the viral infection group and control group(P<0.05).The serum hs-CRP level of the viral infection group was significantly higher than that of the control group(P<0.05),but there was no statistical significance in the difference of PCT level between viral infection group and control group(P >0.05).The positive rates of PCT and hs-CRP in bacterial infection group were significantly higher than those of other 3 groups,the difference was statistically significant(P<0.05).The positive rates of PCT and hs-CRP in the mycoplasma infection group were significantly higher than those of viral infection group and control group,the difference was statistically significant(P<0.05).The positive rate of PCT in the viral infection group was higher than that of the control group with statistical difference(P<0.05),but there was no statistical significance in the difference of hs-CRP positive rate between viral infection group and control group(P >0.05).The area under

关 键 词：降钙素原 超敏C-反应蛋白 急性上呼吸道感染 儿童 

分 类 号：R725.6[医药卫生—儿科]