股骨头坏死骨髓IL-6表达与骨髓水肿分级的相关性研究  

Correlation between Bone Marrow IL-6 Expression and Grade of Bone Marrow Edema in Osteonecrosis of Femoral Head

作　　者：陈恒安 胡海 刘金龙 李华 徐祖健 CHEN Heng-an;HU Hai;LIU Jin-long;LI Hua;XU Zu-jian(Department of Joint Surgery,Hospital of Traditional Chinese Medicine Affiliated to Southwest Medical University,Luzhou 646000,Sichuan,China)

机构地区：[1]西南医科大学附属中医医院关节外科,四川泸州646000

出　　处：《医学信息》2019年第3期65-68,共4页Journal of Medical Information

摘　　要：目的探讨股骨头坏死骨髓白细胞介素6 (IL-6)表达水平与骨髓水肿分级的相关性。方法选取2016年6月～2017年12月就诊于我院骨关节科行多孔髓芯减压术治疗的早期股骨头坏死患者32例作为研究对象,共42髋。术前结合MRI影像分为无骨髓水肿组、骨髓水肿1级组、骨髓水肿2级组及骨髓水肿3级组。所有患者行股骨头钻孔髓芯减压术,术中通过钻孔通道采集股骨头坏死骨髓标本,采用ELISA方法检测骨髓IL-6的表达水平。分析股骨头骨髓IL-6水平与ARCO分期及骨髓水肿分级的相关性。结果 42髋中无骨髓水肿6髋、1级骨髓水肿9髋、2级骨髓水肿12髋及3级骨髓水肿15髋。相关性分析显示ARCO分期与骨髓水肿具有正相关性(r=0.567,P<0.05);骨髓IL-6含量在骨髓水肿各级组间比较有统计学差异(F=63.963,P<0.05)。骨坏死骨髓IL-6表达与骨髓水肿分级呈正相关(r=0.879,P<0.05)。结论骨髓水肿在股骨头坏死ARCO分期进展中发挥重要作用,其发生与骨髓IL-6的表达有关,骨髓IL-6表达可能在推进股骨头坏死病程进展过程中发挥重要作用。Objective To investigate the correlation between the expression of interleukin-6(IL-6)and bone marrow edema in patients with femoral head necrosis.Methods A total of 32 patients with early femoral head necrosis treated with porous core decompression in our department of osteoarthrosis from June 2016 to December 2017 were enrolled.Preoperative combined with MRI images were divided into no bone marrow edema group,bone marrow edema level 1 group,bone marrow edema level 2 group and bone marrow edema level 3 group.All patients underwent core decompression of femoral head drilling,and bone marrow specimens of femoral head necrosis were collected through the drilling channel during operation.The expression level of IL-6 in bone marrow was detected by ELISA.The correlation between IL-6 levels in the femoral head bone marrow and ARCO staging and bone marrow edema grade was analyzed.Results Among the 42 hips,there was no bone marrow edema in 6 hips,grade 1 bone marrow edema in 9 hips,grade 2 bone marrow edema in 12 hips and grade 3 bone marrow edema in 15 hips.Correlation analysis showed that there was a positive correlation between ARCO staging and bone marrow edema(r=0.567,P<0.05),and there was a significant difference in bone marrow IL-6 content between different levels of bone marrow edema(F=63.963,P<0.05).The expression of bone marrow IL-6 in osteonecrosis was positively correlated with the grade of bone marrow edema(r=0.879,P<0.05).Conclusion Bone marrow edema plays an important role in the progression of ARCO stage of femoral head necrosis,which is related to the expression of bone marrow IL-6.The expression of bone marrow IL-6 may play an important role in the progression of osteonecrosis of femoral head.

关 键 词：股骨头坏死 骨髓水肿 IL-6 炎性细胞因子 髓芯减压术 ARCO分期 

分 类 号：R681.8[医药卫生—骨科学]