中老年女性绝经前后骨丢失率变化趋势及与绝经后骨密度的影响因素分析  

Analysis on variation trend of perimenopausal bone loss rate and influencing factors of postmenopausal bone mineral density in middle-aged or elderly female

作　　者：黄国秀[1] 闭应洲 潘永华 吴苏疆 何祺 李卫[1] HUANG Guo-xiu;BI Ying-zhou;PAN Yong-hua;WU Su-jiang;HE Qi;LI Wei(Department of Health Examination Center,the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;School of Computer and Information Engineering,Nanning Normal University,Nanning 530001,China)

机构地区：[1]广西壮族自治区人民医院体检中心,南宁市530021 [2]南宁师范大学计算机与信息工程学院,广西南宁市530001

出　　处：《广西医学》2019年第1期52-55,共4页Guangxi Medical Journal

摘　　要：目的分析中老年女性绝经前后骨丢失率的变化趋势及影响绝经后骨密度的相关因素。方法收集6 849例中老年女性的腰椎骨密度测定资料,其中未绝经女性2 825例(未绝经组),绝经后女性4 024例(绝经组)。比较绝经组和未绝经组骨密度及累计骨丢失率随年龄增长的变化趋势;比较不同绝经年龄的研究对象在相同年龄段时的骨丢失率变化趋势,并分析绝经组的绝经年限、身高、体重、每周户外活动量、牛奶摄入量等因素与骨密度的相关性。结果绝经组和未绝经组女性的骨密度均随着年龄增长逐渐下降,以绝经后各年龄段组的骨密度下降更明显;在41～45岁、46～48岁、49～51岁、52～54岁年龄段,绝经组的骨密度均低于未绝经组(均P <0. 05)。随着年龄增长,绝经组和未绝经组累计骨丢失率均逐渐增加。在51～64岁年龄段,早绝经者相对于晚绝经者的累计骨丢失率均较高;在70～79岁年龄段,46～48岁绝经组和49～51岁绝经组骨丢失率处于一个较为稳定的平台期,而52～54岁绝经组则有一个较为明显的上升过程;各组在80岁后,骨丢失率显示略有回降或上升不明显。绝经年限、经校正年龄因素后的体质指数、每周户外活动时间、每周牛奶摄入量与骨密度均存在相关关系(均P <0. 05)。结论中老年女性的骨丢失率随着年龄增长呈逐渐增加趋势,绝经与否及绝经年龄可影响骨丢失率。较早绝经者比较晚绝经者的累计骨丢失率更高,应对较早绝经者给予全面的骨折风险评估和生活方式干预,以减小其骨丢失率。Objective To analyze variation trend of perimenopausal bone loss rate and influencing factors of postmenopausal bone mineral density in middle-aged or elderly female.Methods The measurement data of lumbar vertebral bone mineral density of 6 849 middle-aged and elderly female,including 2 825 non-menopausal female(non-menopausal group)and 4 024 postmenopausal female(menopausal group),were collected.Variation tendency with age in bone mineral density and cumulative bone loss rate between the menopausal group and the non-menopausal group were compared.Variation trend of bone loss rate at the same age was compared among subjects with different menopausal age.The correlations between menopausal age,height,weight,weekly outdoor activities,milk intake and bone mineral density in the menopausal group were analyzed.Results Bone mineral density of the menopausal group and the non-menopausal group gradually decreased with age,and the decreasing tendency was more obviously in groups of postmenopause with various age.In the 41-45 years old,46-48 years old,49-51 years old,52-54 years old,the bone mineral density of the menopausal group was lower than that of the non-menopausal group,respectively(all P<0.05).With the increase of age,the cumulative bone loss rate of the menopausal group and the non-menopausal group gradually increased.At the age of 51-64 years old,the bone loss rate of the earlier menopause was higher than that of the later menopause;at the age of 70-79 years old,the bone loss rate of the 46-48 years old menopausal group and the 49-51 years old menopausal group were in a relatively stable plateau,while the 52-54 years old menopausal group had a more obvious acceleration process;while at the age of more than 80 years old,the bone loss rate showed a slight decrease or no obvious increase.There were correlations between bone mineral density and menopausal age,body mass index adjusted for age,weekly outdoor activities,and weekly milk intake(all P<0.05).Conclusion The bone loss rate gradually increases with age,whethe

关 键 词：骨丢失 骨密度 绝经 中老年人 女性 

分 类 号：R681[医药卫生—骨科学]