单磷酸阿糖腺苷联合甘露聚糖肽治疗带状疱疹患者的疗效分析  

Effect of arabinosine monophosphate combined with mannan peptide on herpes zoster and inflammatory

作　　者：吴琦琦[1] 陈丽娟[1] 陈利妲[1] WU Qiqi;CHEN Lijuan;CHEN Lida(Department of Skin,the 180th Hospital of PLA,Quanzhou 362000,Fuzhou,China)

机构地区：[1]解放军第180医院皮肤科,福建泉州362000

出　　处：《中南医学科学杂志》2019年第1期68-70,共3页Medical Science Journal of Central South China

摘　　要：分析单磷酸阿糖腺苷联合甘露聚糖肽治疗带状疱疹的效果及对患者免疫球蛋白水平的影响。以本院2014年1月至2017年1月期间诊治的200例带状疱疹患者为研究对象。将患者按照不同的治疗方法分为两组:对照组(n=100)患者给予单磷酸阿糖腺苷、维生素B1/B12和尼美舒利治疗;观察组(n=100)患者在对照组治疗的基础上给予甘露聚糖肽静脉注射。分析两组患者的治疗效果及治疗前后免疫球蛋白水平变化。结果显示:与对照组患者比较,观察组患者的止疱时间、止痛时间、完全结痂时间和皮损痊愈时间明显缩短(P<0.05),有效率明显升高(P<0.05),免疫球蛋白A(IgA)、免疫球蛋白G(IgG)和免疫球蛋白M(IgM)水平也均明显升高(P<0.05)。因此,单磷酸阿糖腺苷联合甘露聚糖肽对带状疱疹的效果明显,且治疗后患者免疫球蛋白水平明显升高。The aim of this study was to analyze the effect of Ara monophosphate combined with mannan peptide on herpes zoster and its influence on immunoglobulin levels. The patients with herpes zoster diagnosed and treated in our hospital from January 2014 to January 2017 were selected as the research subjects. 200 patients were randomly divided into two groups according to the treatment. Patients in the control group (n =100) were treated with adenosine monophosphate, vitamin B1/ B12 and Ni Mei Shug Leigh. The patients in the observation group (n =100) were given mannan peptide intravenously on the basis of the control group??s treatment. The effect of two groups on herpes zoster and the changes of immunoglobulin levels was analyzed before and after treatment. The results showed that compared with the control group, the blister relief time, pain relief time, complete scab formation time and skin healing time were significantly shortened (P<0. 05), and the effective rate was significantly increased (P<0. 05), the levels of IgA, IgG and IgM were significantly increased (P<0. 05). So Adenosine monophosphate (AMP) combined with mannosine peptide has a significant effect on herpes zoster, and the levels of immunoglobulin in patients with herpes zoster are significantly decreased after treatment.

关 键 词：单磷酸阿糖腺苷 甘露聚糖肽 带状疱疹 免疫球蛋白 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]