茵栀黄口服液治疗妊娠期胆汁淤积症临床疗效分析  

Clinical efficacy of the Yinzhihuang oral liquid on ICP

作　　者：黄越前[1] 纪华英 苏春宏[1] 李桂娥 Huang Yueqian

机构地区：[1]广州医科大学附属第三医院,广东广州510150

出　　处：《中医临床研究》2019年第1期7-10,共4页Clinical Journal Of Chinese Medicine

摘　　要：目的:观察茵栀黄口服液治疗妊娠期肝内胆汁淤积症的疗效,探讨其在ICP治疗中的作用机理,为临床上治疗ICP提供理论和临床依据。方法:本研究拟采用前瞻性同期对照非随机的研究方法,将2015年2月-2017年5月我院收治的106例妊娠期胆汁淤积症孕妇分为4组。即根据用药方法分为A组26例、B组27例、C组25例、D组28例。A组孕妇给予茵栀黄口服液联合综合法治疗,B组孕妇在A组的基础上联合熊去氧胆酸治疗;C组孕妇给予UDCA治疗联合综合治疗,D组孕妇给予综合治疗,分别记录并对比治疗前后各试验检测指标及妊娠结局、瘙痒情况。结果:治疗后,A组与B组的痊愈率分别是46.15%,51.85%,总有效率为88.46%,92.59%,均明显高于C组与D组的24.00%,0.00%及64.00%,28.57%(均P <0.05);治疗前四组各生化指标差异均无统计学意义,治疗后4组各生化指标均明显降低,且A组与B组下降幅度均明显优于C组与D组(P <0.05);治疗前4组孕妇出现皮肤瘙痒差异无统计学意义,治疗1周及2周后均有不同程度的降低,A组与B组的下降幅度均大于C组与D组(均P <0.05);治疗后妊娠结局中,除围产儿病死率外,A组与B组胎儿窘迫、新生儿窒息与早产及羊水污染发生率均明显低于C组与D组(均P <0.05)。结论:茵栀黄口服液联合综合治疗与茵栀黄口服液、UDCA及综合治疗三种措施联合方案不仅治疗效果显著,还有效降低了患者妊娠期的各生化指标,同时有效改善了患者皮肤瘙痒的痛苦与妊娠结局,安全性更佳。Objective:To observe clinical effects of the Yinzhihuang oral liquid(茵栀黄口服液)on intrahepatic cholestasis in pregnancy.Methods:106 patients with intrahepatic cholestasis in pregnancy were randomly divided into 4 groups by a prospective controlled nonrandomized methods in the same period.The group A was treated with the Yinzhihuang oral liquid plus comprehensive method.The group B was treated with ursodeoxycholic acid more.The group C was treated with ursodeoxycholic acid plus comprehensive method.The group D was treated by comprehensive method.Results:The recovery rate individually was 46.15%and 51.85%in the group A and group B,higher than 24.00%and 0.00%in the group C and group D.The total efficiency rate individually was 88.46%and 92.59%in the group A and group B,higher than 64.00%and 28.57%in the group C and group D(P<0.05).There was no statistically significant difference of the biochemical indexes among 4 groups before treatment.After treatment,biochemical indexes were significantly decreased in 4 groups.The decreasing degrees of the biochemical indexes in the group A and group B were more than those in the group C and group D.There was no statistically significant difference of the rate of cutaneous pruritus before treatment.The cutaneous pruritus was decreased in the 4 groups after treatment in 1 or 2 weeks.The decreasing degrees of the cutaneous pruritus in the group A and group B were more than those in the group C and group D.The incidences of fetal distress,neonatal asphyxia,preterm birth and amniotic fluid contamination in the group A and group B were less than those in the group C and group D(P<0.05),outside perinatal mortality rate.Conclusion:The Yinzhihuang oral liquid on intrahepatic cholestasis of pregnancy is effective,safe and worthy of promotion.

关 键 词：茵栀黄口服液 熊去氧胆酸 妊娠 胆汁淤积 

分 类 号：R246.2[医药卫生—针灸推拿学]