甘氨酰谷氨酰胺有关物质的结构鉴定与合成  

Structural Identification and Synthesis of Related Substances of Glycyl Glutamine

作　　者：王智军 赵立伟 王帅军 李晨光 王云鹏 Wang Zhijun;Zhao Liwei;Wang Shuaijun;Li Chenguang;Wang Yunpeng(Shandong Wego Pharmaceutical Co.,Limited,Weihai264210,China)

机构地区：[1]山东威高药业股份有限公司,山东威海264210

出　　处：《山东化工》2019年第2期44-45,共2页Shandong Chemical Industry

摘　　要：在甘氨酰谷氨酰胺质量研究中,通过高温破坏,分析了3个主要的降解杂质,其中一个通过LC-MS分析,推测其结构为了环-(甘氨酰-谷氨酸)。以甘氨酰谷氨酰胺为原料,经过酯化、氨解成环得到了有关物质A环-(甘氨酰-谷氨酰胺),再经碱性水解得到有关物质B环-(甘氨酰-谷氨酸)。还以谷氨酸为原料,合成了有关物质C甘氨酰谷氨酸。这些杂质结构经1H NMR、13C NMR、MS和IR确证。In the quality study of Glycyl Glutamine,three main impurities were analyzed through high temperature degradation,one new impurity was identified by HPLC-MS,and the structure was speculated to be cyclo(glycyl-glutamic acid).Related substance A cyclo(glycyl-g lutamine)was synthesized from glycyl glutamine via esterification and ring-closure reaction with amine,after base catalyzed hydrolysis got related substance B cyclo(glycyl-glutamic acid).Related substance C glycyl-glutamic acid was synthesized from glutamic acid.The structure of these related substances were confirmed by 1H NMR、13 13C NMR、MS and IR.

关 键 词：甘氨酰谷氨酰胺 有关物质 合成 

分 类 号：TQ463[化学工程—制药化工]