microRNA对动物生殖轴以及胚胎着床影响的研究进展  

Advance in Effects of microRNA on Reproductive Axis and Embryo Implantation

作　　者：向光明 刘秋月[1] 王翔宇[1] 狄冉[1] 胡文萍[1] 曾宪垠[2] 曹晓涵[2] 储明星[1] XIANG Guang-ming;LIU Qiu-yue;WANG Xiang-yu;DI Ran;HU Wen-ping;ZENG Xian-yin;CAO Xiao-han;CHU Ming-xing(Key Laboratory of Animal Genetics,Breeding and Reproduction of Ministry of Agriculture,Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193,China;Life Science College,Sichuan Agricultural University,Sichuan Ya′an 625014,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所农业部动物遗传育种与繁殖重点实验室,北京100193 [2]四川农业大学生命科学学院,四川雅安625014

出　　处：《中国畜牧杂志》2019年第1期1-8,共8页Chinese Journal of Animal Science

基　　金：国家自然科学基金项目(31702085);中国博士后科学基金面上项目(2016M591308);国家肉羊产业技术体系专项(CARS-38);中国农业科学院科技创新工程(ASTIPIAS13);农业科研杰出人才及其创新团队项目(农办人[2015]62号);国家万人计划科技创新领军人才项目(W02020274)

摘　　要：表观调控作为调节基因功能的一种重要手段,其对生殖内分泌方面的调控起着重要作用。microRNA(miRNA)作为一类小的非编码RNA,也是一种表观遗传因子,它广泛参与生物体内各种生理及病理过程,对哺乳动物繁殖起着重要的调控作用。本文围绕miRNA在哺乳动物繁殖相关组织的表达及调控作用和miRNA对胚胎着床的影响进行综述,为理解miRNA对繁殖方面的表观调控、改善哺乳动物繁殖能力提供理论基础。As an important way of regulating gene expression,epigenetic regulation in reproductive endocrinology has been increasingly reported.MiRNA is one kind of small non-coding RNAs and also an epigenetic factor which can participate in many pathological and physiological processes.Many studies had confirmed that miRNA plays an important regulatory role in mammalian reproduction.In this review,we present the expression levels of miRNA in mammalian reproductive organs,and effects on embryo implantation of miRNAs.It can contribute to our understanding of epigenetic regulation of miRNAs in reproduction,which may provide a theoretical basis for improving mammalian reproductive capacity.

关 键 词：表观调控 MIRNA 哺乳动物繁殖 胚胎着床 

分 类 号：S814[农业科学—畜牧学]