QFT-GIT对儿童肺结核临床诊断价值的meta分析  

Clinical Usefulness of QuantiFERON-TB Gold In-Tube(QFT-GIT)Testfor Tuberculosis Diagnosis in Children:A Systematic Review

作　　者：田斌[1] 文岚[1] 刘燕萍[1] 黄非凡 张兵[1] TIAN Bin;WEN Lan;LIU Yan-ping;HUANG Fei-fan;ZHANG Bing(Changsha Center for Disease Control and Prevention,Changsha 410001,China)

机构地区：[1]长沙市疾病预防控制中心,长沙410001

出　　处：《现代检验医学杂志》2019年第1期89-92,96,共5页Journal of Modern Laboratory Medicine

摘　　要：目的系统评价QFT-GIT对儿童肺结核临床诊断价值。方法计算机检索中国生物医学数据库、中国知网(CNKI)全文数据库、维普数据库、万方全文数据库、EMBASE,PUBMED和Cochrane并提取数据,应用Stata软件进行meta分析。结果分析纳入的5个研究。结果显示,QFT-GIT作为儿童肺结核诊断试验,灵敏度点估计值为0.76,95%CI=0.65～0.84,特异度点估计值为0.98,95%CI=0.91～1.00。另外,阳性似然比点估计值为42.0,95%CI=8.5～207.8,阴性似然比点估计值为0.25,95%CI=0.17～0.37,诊断优势比OR=169,95%CI=37～775。结论 QFT-GIT具有排除诊断的能力,但鉴于受试儿童免疫状态和感染风险的差异会造成其检测能力表现存在差异,建议对该方法进行进一步评价。Objective This study performed a meta-analysis to evaluate the efficacy of QuantiFERON-TB Gold In-Tube(QFTGIT)test for detecting Tuberculosisin children.Methods The research was reported according to the preferred reporting items for systematic reviews and meta-analysis guidelines by Stata soft wear.Chinese Biomedical Database(CBMDISC),Pubmed,EMBASE,Cochrane,CNKI,VIP database,WANFANG full-text database were searched up to August 6,2018 and the useful data were extracted by three people.Results Five studies including one RCT and four non-RCTs were included in this study.The present meta-analysis of QuantiFERON-TB Gold In-Tube test for detecting Tuberculosis in children indicated that the sensitivity was equal to 0.76,95%CI=0.65~0.84,the specificity was equal to 0.98,95%CI=0.91~1.00,the positive likelihood ratio was equal to 42.0,95%CI=8.5~207.8,the negative likelihood ratio was equal to 0.25,95%CI=0.17~0.37 and the Diagnostic Odds Ratio was equal to 169,95%CI=37~775.Conclusion Recommend that QFT-GIT should be evaluated further’cos the difference of utility performance for immune status and infection risk between the children who was undergo the detecting,although it has the ability to rule out suspicious patients.

关 键 词：META分析 QuantiFERON-TB GOLD In-Tube 结核分枝杆菌 诊断试验 

分 类 号：R521[医药卫生—内科学] R446[医药卫生—临床医学]