短管兔耳草化学成分的研究  

Chemical constituents from Lagotis brevituba

作　　者：张晨辉 李敏 曾金祥 谢雄雄 毛竹 钟国跃 ZHANG Chen-hui;LI Min;ZENG Jin-xiang;XIE Xiong-xiong;MAO Zhu;ZHONG Guo-yue(The Research Center of Chinese Medicine Resource and National Medicine,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学中药资源与民族药研究中心,江西南昌330004

出　　处：《中成药》2019年第2期333-337,共5页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金项目(81660648);江西省自然科学基金项目(20171BAB205090);江西中医药大学民族药协同创新项目(JXXT2018001;JXXT201402022);江西中医药大学研究生创新专项资金项目(JZYC18S11)

摘　　要：目的研究短管兔耳草Lagotis brevituba Maxim的化学成分。方法短管兔耳草70%乙醇提取物采用硅胶、Sephadex LH-20、MCI柱和制备液相色谱进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到10个化合物,分别鉴定为3,4-二甲氧基苯甲醛(1)、3,4-二甲氧基苯丙酸(2)、阿魏酸甲酯(3)、邻苯二甲酸二丁酯(4)、木犀草素(5)、柯伊利素-7-O-β-D-吡喃葡萄糖苷(6)、香叶木素-7-O-β-D-吡喃葡萄糖苷(7)、4-p-香豆酸-O-α-D-吡喃葡萄糖苷(8)、4-p-香豆酸-O-β-D-吡喃葡萄糖苷(9)、6-O-[α-L-(3-3,4-二甲氧基肉桂酰)-吡喃鼠李糖基]-梓醇(10)。结论化合物2～4、8～10为首次从该属分离得到,化合物1～4、8～10为首次从该植物中分离得到。AIM To study the chemical constituents from Lagotis brevituba Maxim.METHODS The 70%ethanol extract of L.brevituba was isolated and purified by silica gel,Sephadex LH-20,MCI column and preparative liquid chromatography,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Ten compounds were isolated and identified as 3,4-dimethoxybenzaldehyde(1),3,4-dimethoxy phenylpropionic acid(2),methyl ferulic acid(3),dibutyl phthalate(4),luteolin(5),chrysoeriol-7-O-β-D-glucoside(6),diosmetin-7-O-β-D-glucopyranoside(7),4-p-cumaroyl-O-α-D-glucose(8),4-p-cumar-oyl-O-β-D-glucose(9),6-O-[α-L-(3-3,4-dimethoxycinnamoyl)-rhamnopyranosy]-catalpol(10).CONCLUSION Compounds 2-4、8-10 are isolated from genus Lagotis for the first time,and compounds1-4、8-10 are isolated from this plant for the first time.

关 键 词：短管兔耳草 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]