慢性乙型肝炎患者血清中透明质酸、前白蛋白的水平与HBV-DNA载量的相关性分析  

Correlation between serum hyaluronic acid,prealbumin levels and HBV-DNA load in patients with chronic hepatitis B

作　　者：叶健翔[1] 黄志伟[1] 梁启兰 沓世念[1] YE Jianxiang;HUANG ZHiwei;LIANG Qilan(Second People's Hospital of Zhaoqing City,Guangdong Province,Zhaoqing 526060,China.)

机构地区：[1]广东省肇庆市第二人民医院,肇庆526060

出　　处：《江西医药》2019年第1期27-29,共3页Jiangxi Medical Journal

基　　金：广东省肇庆市科技创新计划项目;编号00208051150419039

摘　　要：目的探讨慢性乙型肝炎患者血清中透明质酸、前白蛋白的水平与HBV-DNA载量的相关性。方法选取2015年4月至2016年5月在肇庆市第二人民医院门诊和住院的慢性乙肝患者200例为观察组,同期于肇庆市第二人民医院行健康体检的肝脏功能正常者120例为对照组,检测两组血清HBV-DNA水平与透明质酸及前白蛋白水平,分析其相关性。结果观察组患者的血清前白蛋白水平(125.66±23.45)mg/L,低于对照组的(311.43±28.56)mg/L,差异有统计学意义(t=58.779,P<0.001)。观察组患者的血清HBV-DNA水平与肝纤维化指标透明质酸均高于对照组,差异有统计学意义(P<0.05)。3组不同血清HBV-DNA水平患者的透明质酸浓度对比,差异有统计学意义(P<0.05);且随着患者血清HBV-DNA水平的增高,透明质酸逐渐增高。3组不同血清HBV-DNA水平患者的前白蛋白浓度对比,差异有统计学意义(P<0.05);且随着患者血清HBV-DNA水平的增高,前白蛋白逐渐降低。慢性乙型肝炎患者血清HBV-DNA水平与透明质酸正相关,与前白蛋白呈负相关(P<0.05)。结论慢性乙型肝炎患者血清HBV-DNA水平与透明质酸、前白蛋白存在相关性,有效控制患者血清HBV-DNA水平能延缓肝纤维化的发展。Objective To investigate the correlation between serum hyaluronic acid and prealbumin levels and HBV-DNA load in patients with chronic hepatitis B.Methods A total of 200 patients with chronic hepatitis B who were admitted to the outpatient clinic and ward of Zhaoqing City Second People's Hospital from April 2015 to May 2016 were selected as observation group.120 patients with normal liver function in our hospital during the same period were used as controls.In the group,serum HBV-DNA levels and hyaluronic acid and prealbumin levels were measured and analyzed for correlation.Results Serum prealbumin levels(125.66±23.45)mg/L were observed in the observation group,which was lower than that in the control group(311.43±28.56)mg/L.The difference was statistically significant(t=58.779,P<0.001).The serum HBV-DNA level and the liver fibrosis index hyaluronic acid were higher in the observation group than in the control group,and the difference was statistically significant(P<0.05).The difference of hyaluronic acid concentration between the three groups of patients with different serum HBV-DNA levels was statistically significant(P<0.05);and with the increase of serum HBV-DNA levels,hyaluronic acid gradually increased.The difference in prealbumin concentration between the three groups of patients with different serum HBV-DNA levels was statistically significant(P<0.05);and with the increase of serum HBV-DNA levels,prealbumin decreased gradually.Serum HBV-DNA levels in patients with chronic hepatitis B were positively correlated with hyaluronic acid and negatively correlated with prealbumin(P<0.05).Conclusion Serum HBV-DNA levels in patients with chronic hepatitis B have a certain correlation with hyaluronic acid and prealbumin.Therefore,effective control of serum HBV-DNA levels can delay the development of liver fibrosis.

关 键 词：慢性乙型肝炎 血清HBV-DNA 肝纤维化 相关性 

分 类 号：R512.62[医药卫生—内科学]