妊娠特异性β1糖蛋白及脐动脉血流S/D值在妊娠晚期胎儿-胎盘监测中的价值  

Value of pregnancy specific β1 glycoprotein and umbilical S/D in fetal-placenta monitoring during late pregnancy

作　　者：庞远 李海朋[2] 董亚男[2] 肖秀娟[2] PANG Yuan;LI Hai-peng;DONG Ya-nan(Department of Ultrasonic Diagnosis,North China University of Technology Hospital,Tangshan Hebei 063210,China;Department of Ultrasonic Diagnosis,Department of Ultrasonography,Union Medical College Hospital,Tangshan Hebei 063000,China)

机构地区：[1]华北理工大学医院超声诊断科,河北唐山063210 [2]唐山市协和医院超声诊断科,河北唐山063000

出　　处：《临床和实验医学杂志》2019年第4期436-439,共4页Journal of Clinical and Experimental Medicine

基　　金：河北省卫生和计划生育委员会科研基金项目(编号:20160880)

摘　　要：目的探讨妊娠特异性β1糖蛋白(SP1)及脐动脉血流速度收缩末期峰值(S)与舒张末期峰值(D)的比值(S/D值)在妊娠晚期胎儿-胎盘监测中的价值。方法回顾性分析2015年1月至2016年12月在唐山市协和医院进行产前检查并住院分娩的178例孕产妇资料,根据是否合并妊娠综合征将其分为健康妊娠组90例,妊娠合并症组88例(其中妊娠糖尿病组17例,羊水过少组23例,宫内发育迟缓组9例,轻度子痫前期组25例,重度子痫前期组14例),观察比较两组孕产妇不良结局的发生率和两组胎儿或新生儿不良结局发生率,观察SP1及脐动脉血流S/D值对患者妊娠结局的影响。结果健康妊娠组早产(4. 4%vs. 14. 7%)、胎膜早破(12. 2%vs. 22. 7%)、产后出血(2. 2%vs. 10. 2%)以及贫血(7. 8%vs. 15. 9%)发生率明显低于妊娠合并症组(P <0. 05),健康妊娠组宫内窘迫(7. 8%vs. 29. 5%)及新生儿窒息(5. 6%vs. 20. 4%)发生率明显低于妊娠合并症组(P <0. 05);宫内发育迟缓组(92. 42±12. 35 mg/L)、重度子痫前期组(89. 39±10. 91 mg/L) SP1明显低于健康妊娠组(124. 52±12. 41 mg/L)(P <0. 05),妊娠糖尿病组(3. 24±0. 36)、羊水过少组(3. 24±0. 51)、宫内发育迟缓组(3. 01±0. 32)、重度子痫前期组(3. 81±0. 72) S/D值明显低于健康妊娠组(P <0. 05),这4组宫内窘迫及新生儿窒息发生率也较健康妊娠组明显升高(P <0. 05)。结论妊娠晚期对孕产妇进行SP1及脐动脉血流S/D值检测可预测妊娠结局。Objective To investigate value of pregnancy-specificβ1 glycoprotein(SP1)and systolic to diastolic(S/D)ratios of umbilical velocimetry in fetal-placental monitoring during late pregnancy.Methods 178 cases of pregnancy in our center from January 2015 to December 2016 were retrospectively selected and divided into healthy pregnancy group(n=90)and pregnancy comorbidity group(n=88)(17 cases of gestational diabetes mellitus,23 cases of oligohydramnios group,9 cases of intrauterine growth retardation,25 cases of mild preeclampsia group,14 cases of severe preeclampsia group),and observed adverse outcome incidence for both mothers neonates.Effect of SP1 and umbilical S/D ratios on pregnancy outcomes were compared.Results For mothers,premature delivery(4.4%vs.14.7%),premature rupture of membranes(12.2%vs.22.7%),postpartum hemorrhage(2.2%vs.10.2%),and anemia(7.8%vs.15.9%)were significantly lower in healthy pregnancy group(P﹤0.05).For neonates,incidence of intrauterine distress(7.8%vs.29.5%)and neonatal asphyxia(5.6%vs.20.4%)in healthy pregnancy group was lower than in pregnancy comorbidity group(P﹤0.05).SP1 in intrauterine growth retardation group(92.42±12.35 mg/L)and severe preeclampsia group(89.39±10.91 mg/L)were lower than in healthy pregnancy group(124.52±12.41 mg/L)(P﹤0.05).S/D values in the gestational diabetes group(3.24±0.36),oligohydramnios group(3.24±0.51),intrauterine growth retardation group(3.01±0.32),and severe preeclampsia group(3.81±0.72)were significantly lower and with higher incidence of intrauterine distress and neonatal asphyxia compared with healthy pregnancy group(P﹤0.05).Conclusion SP1 and of umbilical S/D ratio in pregnant women during the third trimester of pregnancy can predict pregnancy outcome.

关 键 词：妊娠晚期 胎儿-胎盘监测 妊娠特异性Β1糖蛋白 脐动脉血流S/D值 

分 类 号：R714.5[医药卫生—妇产科学]