氨基葡萄糖、硫酸软骨素联合骨健康操可提高绝经后女性骨密度和肌肉力量:一项社区干预试验  

Glucosamine,chondroitin sulfate combined with bone health exercise can promote bone mineral density and muscle strength in postmenopausal women:a random community trial

作　　者：刘峰[1] 黄小明 凌斌[1] Liu Feng;Huang Xiaoming;Ling Bin(School of Clinical Medicine,Chongqing Medical and Pharmaceutical College,Chongqing 401331,China;Department of Nutrition and Food Hygiene,School of Public Health,Southwest Medical University,Luzhou 646000,Sichuan Province,China)

机构地区：[1]重庆医药高等专科学校临床医学院,重庆市401331 [2]西南医科大学公共卫生学院营养与食品卫生教研室,四川省泸州市646000

出　　处：《中国组织工程研究》2019年第15期2303-2307,共5页Chinese Journal of Tissue Engineering Research

基　　金：重庆市科技计划项目(16YY071);项目负责人:凌斌~~

摘　　要：背景:氨基葡萄糖和硫酸软骨素是软骨组织的重要组成成分,动物实验还证实其具有协同治疗骨质疏松的功效,但其药物联合规律运动对绝经后女性骨关节健康的作用国内外研究较少。目的:利用社区干预试验观察氨基葡萄糖、硫酸软骨素联合骨健康操对绝经后女性骨骼和关节健康的影响。方法:2016年1至6月按整群抽样的方法随机抽取重庆市璧山区符合条件的绝经后女性206人,利用随机数字法分为干预组和对照组,干预组给予氨基葡萄糖硫酸软骨素胶囊3粒/d,并进行每周不低于3次的骨健康操,对照组不给予特殊处理,干预6个月后比较2组骨密度、惯用膝肌肉力量、骨折、骨关节炎和跌倒发生率及功能症状评级。肌肉力量采用ISOMED-2000等速肌力测试系统获取惯用膝在角速度0 (°)/s和60 (°)/s屈膝、伸膝时经体质量校正的峰力矩数据。结果与结论:①干预6个月后干预组骨密度高于对照组,在角速度0 (°)/s和60 (°)/s时干预组伸膝和屈膝峰力矩均高于对照组(P<0.05);②干预6个月内对照组跌倒发生率高于干预组(17.00%vs.5.94%,P<0.05),而骨折和骨关节炎发生率两组差异无显著性意义(P> 0.05);③2组对象干预6个月后关节疼痛、肌肉支撑力、行走距离和关节僵硬自评分级差异有显著性意义(P <0.05);④结果说明,氨基葡萄糖和硫酸软骨素结合规律骨健康操能一定程度上提高绝经后女性骨密度和肌肉力量、预防发生关节疼痛或僵硬等症状,从而预防绝经后女性跌倒、骨折和骨关节炎的发生。BACKGROUND:Glucosamine and chondroitin sulfate are important compositions of cartilage tissues.Animal experiments have shown that glucosamine and chondroitin sulfate can treat osteoporosis synergistically,but the effect of their combinations with regular exercise on the bone and joint health of menopausal women is little reported.OBJECTIVE:To observe the effects of the combination of glucosamine,chondroitin sulfate and bone health exercises on skeletal and joint health in postmenopausal women by a random community trial.METHODS:From January to June 2016,206 eligible postmenopausal women were selected from Bishan District of Chongqing and randomly divided into two groups by random digital method.The trial group received glucosamine and chondroitin sulfate(3 capsules/day,and bone health exercises(at least 3 times/week),while the control group did not receive special treatment.After 6 months of intervention,the bone mineral density,muscle strength of habitual knee,incidence of fracture,osteoarthritis and fall,and levels of symptom and function were compared between the two groups.The peak torque of extension and flexion of habitual knee at 0 and 60(°)/s angular velocity was detected using Isomed 2000 Dynamometer.RESULTS AND CONCLUSION:(1)The bone mineral density and the peak torque of extension and flexion of habitual knee at 0 and 60(°)/s angular velocity in the trial group were significantly higher than those in the control group at 6 months after treatment(P<0.05).(2)The incidence of fall in the trail group was lower than that in the control group at 6 months(17.00% vs.5.94%,P<0.05).The incidence of fracture and osteoarthritis had no significant difference between two groups(P >0.05).(3)The self-ranking of joint pain,holding power of muscle,walking distance and joint stiff had significant differences between two groups(P<0.05).(4)These results indicate that glucosamine and chondroitin sulfate supplements combined with regular bone health exercises can improve bone mineral density and muscle strength,and prevent

关 键 词：绝经后女性 氨基葡萄糖 硫酸软骨素 骨质疏松症 骨健康操 等速肌力测试 肌肉力量 骨质疏松 绝经后 氨基糖类 软骨素硫酸盐类 

分 类 号：R496[医药卫生—康复医学]