硫氧还蛋白系统在动脉粥样硬化中的研究进展  

Research progress of thioredoxin system in atherosclerosis

作　　者：杨阳[1] 张慧[1] 侯静波[1] YANG Yang;ZHANG Hui;HOU Jing-bo(Department of Cardiology,Second Affiliated Hospital of Harbin Medical University,Ministry of Education Key Laboratory of Myocardial Ischemia Established by Province and Ministry,Harbin,Heilongjiang,150001,China)

机构地区：[1]哈尔滨医科大学附属第二医院心内科/心肌缺血省部共建教育部重点实验室,黑龙江哈尔滨150001

出　　处：《心血管康复医学杂志》2019年第1期117-119,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：硫氧还蛋白是细胞内重要的二硫键还原酶之一,在抗细胞的氧化应激、维持细胞内蛋白质的还原状态并正常发挥功能起着重要的作用。本文从硫氧还蛋白的抗氧化、抗凋亡、抗炎以及调节血脂血糖代谢等方面阐述其在动脉粥样硬化中可能具有的生物学功能,从而为防治动脉粥样硬化提供新的靶点。Thioredoxin is one of important disulfide bond reductases in cells,which plays important role in antioxidant stress of cells and maintaining reduced state of intracellular protein and its normal functioning.The present article set forth the possible biological function of thioredoxin in atherosclerosis from its antioxidation,anti-apoptosis,anti-inflammation and regulation of blood lipid and glucose metabolism etc.,aiming at providing new targets for prevention and treatment of atherosclerosis.

关 键 词：硫氧还蛋白 动脉粥样硬化 氧化性应激 

分 类 号：R541.1[医药卫生—心血管疾病]